The majority of triple-negative breast cancer may correspond to basal-like carcinoma, but triple-negative breast cancer is not identical to basal-like carcinoma - PubMed (original) (raw)

The majority of triple-negative breast cancer may correspond to basal-like carcinoma, but triple-negative breast cancer is not identical to basal-like carcinoma

Naoto Kuroda et al. Med Mol Morphol. 2009 Jun.

Abstract

Recently, the concept of basal-like carcinoma has been proposed. However, there are only a few reports about the relationship between triple-negative cancer and basal-like carcinoma. In this article, we report the study of the expression of basal cell markers in 11 triple-negative cancers. Eight tumors (4 metaplastic carcinomas, 2 invasive ductal carcinomas, 1 invasive papillary carcinoma, and 1 medullary carcinoma) were positive for more than three markers among cytokeratins 5, 14, and 17, and p63. Three tumors (2 invasive ductal carcinomas and 1 apocrine carcinoma) were completely negative for all markers. Among 8 tumors positive for basal markers, cytokeratins 5 and 17 were expressed in all 8 tumors, cytokeratin 14 in 6 tumors, and p63 in 7 tumors. Finally, we conclude that the majority of triple-negative cancer may correspond to basal-like carcinoma, but the two entities are not identical. The use of combination immunohistochemistry including cytokeratins 5, 14, and 17 and p63 may contribute to the detection of basal-like carcinoma.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10393-8 - PubMed
    1. Histopathology. 2008 Jan;52(1):108-18 - PubMed
    1. Clin Cancer Res. 2005 Jun 1;11(11):4003-11 - PubMed
    1. Histopathology. 2008 Jan;52(1):91-8 - PubMed
    1. Histopathology. 2005 Nov;47(5):458-66 - PubMed

MeSH terms

Substances

LinkOut - more resources