Vaccination in the elderly: an immunological perspective - PubMed (original) (raw)

Review

Vaccination in the elderly: an immunological perspective

Wilbur H Chen et al. Trends Immunol. 2009 Jul.

Abstract

Successful vaccination of the elderly against important infectious pathogens that cause high morbidity and mortality represents a growing public health priority. Building on the theme of aging and immunosenescence, we review mechanisms of human immunosenescence and the immune response to currently licensed vaccines. We discuss the difficulties in identifying the risk factors that, in addition to aging, cause immunosenescence and address the relative paucity of vaccine studies in the elderly. We conclude that vaccine responses are blunted in the elderly compared with that of healthy young adults. However, it is also clear that our understanding of the mechanisms underlying immunosenescence is limited and much remains to be learned to improve the effectiveness of next generation vaccines.

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References

1. Nichol KL, et al. Effectiveness of influenza vaccine in the community-dwelling elderly. N. Engl. J. Med. 2007;357:1373–1381. - PubMed
1. Goronzy JJ, et al. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J. Virol. 2001;75:12182–12187. - PMC - PubMed
1. Saurwein-Teissl M, et al. Lack of antibody production following immunization in old age: association with CD8(+)CD28(−) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J. Immunol. 2002;168:5893–5899. - PubMed
1. Trzonkowski P, et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination--an impact of immunosenescence. Vaccine. 2003;21:3826–3836. - PubMed
1. Cortesini R, et al. CD8+CD28- T suppressor cells and the induction of antigen-specific, antigen-presenting cells-mediated suppression of Th reactivity. Immunol. Rev. 2001;182:201–206. - PubMed

Vaccination in the elderly: an immunological perspective - PubMed (original) (raw)