What are the roles of microRNAs at the mammalian synapse? - PubMed (original) (raw)
Review
. 2009 Dec 4;466(2):63-8.
doi: 10.1016/j.neulet.2009.06.050. Epub 2009 Jun 21.
Affiliations
- PMID: 19545603
- DOI: 10.1016/j.neulet.2009.06.050
Review
What are the roles of microRNAs at the mammalian synapse?
Anetta Konecna et al. Neurosci Lett. 2009.
Abstract
The modification of neuronal connections in response to stimuli is believed to be the basis of long-term memory formation. It is currently accepted that local protein synthesis critically contributes to site-restricted modulation of individual synapses. Here, we summarize recent evidence implicating miRNAs in this process, leading to altered dendrite morphogenesis and synaptic plasticity. Second, we discuss findings in non-neuronal systems about how RNA-binding proteins can modulate miRNA-mRNA interactions, and how these mechanisms might apply to neurons. Finally, we review recent findings that P-bodies may be important sites for miRNA action at the synapse.