Progesterone inhibits activation-induced deaminase by binding to the promoter - PubMed (original) (raw)
. 2009 Jul 15;183(2):1238-44.
doi: 10.4049/jimmunol.0803915. Epub 2009 Jun 24.
Affiliations
- PMID: 19553525
- DOI: 10.4049/jimmunol.0803915
Progesterone inhibits activation-induced deaminase by binding to the promoter
Siim Pauklin et al. J Immunol. 2009.
Abstract
Regulation of activation-induced deaminase (AID), an essential factor in Ig diversification, can alter not only somatic hypermutation and class switch recombination (CSR), but may also influence oncogenesis. AID deaminates cytosine to uracil in the Ig locus, thereby initiating Ig diversification. Unregulated AID can induce oncogenic DNA alterations in Ig and non-Ig loci, leading to mutations, recombination, and translocations. In this study, we demonstrate that AID mRNA production in activated mouse splenic B cells can be reduced by treatment with the sex hormone progesterone. This down-regulation is independent of translation or splicing and is predominantly achieved by inhibiting transcription. During cell treatment we could detect progesterone receptor bound to the AID promoter in proximity to NF-kappaB binding. Importantly, the progesterone-induced repression was also extended to the protein level of AID and its activity on somatic hypermutation and class switch recombination.
Similar articles
- Negative regulation of activation-induced cytidine deaminase in B cells.
Muto T, Okazaki IM, Yamada S, Tanaka Y, Kinoshita K, Muramatsu M, Nagaoka H, Honjo T. Muto T, et al. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2752-7. doi: 10.1073/pnas.0510970103. Epub 2006 Feb 13. Proc Natl Acad Sci U S A. 2006. PMID: 16477013 Free PMC article. - Activation-induced deaminase: light and dark sides.
de Yébenes VG, Ramiro AR. de Yébenes VG, et al. Trends Mol Med. 2006 Sep;12(9):432-9. doi: 10.1016/j.molmed.2006.07.001. Epub 2006 Jul 24. Trends Mol Med. 2006. PMID: 16861038 Review. - Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies.
Durandy A, Taubenheim N, Peron S, Fischer A. Durandy A, et al. Adv Immunol. 2007;94:275-306. doi: 10.1016/S0065-2776(06)94009-7. Adv Immunol. 2007. PMID: 17560278 Review. - Single-strand DNA breaks in Ig class switch recombination that depend on UNG but not AID.
Arudchandran A, Bernstein RM, Max EE. Arudchandran A, et al. Int Immunol. 2008 Nov;20(11):1381-93. doi: 10.1093/intimm/dxn097. Epub 2008 Sep 15. Int Immunol. 2008. PMID: 18794203 - Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.
Wakae K, Magor BG, Saunders H, Nagaoka H, Kawamura A, Kinoshita K, Honjo T, Muramatsu M. Wakae K, et al. Int Immunol. 2006 Jan;18(1):41-7. doi: 10.1093/intimm/dxh347. Epub 2005 Nov 15. Int Immunol. 2006. PMID: 16291656
Cited by
- Nuclear Receptors, Ligands and the Mammalian B Cell.
Jones BG, Penkert RR, Surman SL, Sealy RE, Hurwitz JL. Jones BG, et al. Int J Mol Sci. 2020 Jul 15;21(14):4997. doi: 10.3390/ijms21144997. Int J Mol Sci. 2020. PMID: 32679815 Free PMC article. Review. - Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications.
Xiao T, Lee J, Gauntner TD, Velegraki M, Lathia JD, Li Z. Xiao T, et al. Nat Rev Cancer. 2024 May;24(5):338-355. doi: 10.1038/s41568-024-00680-z. Epub 2024 Apr 8. Nat Rev Cancer. 2024. PMID: 38589557 - Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity.
Casellas R, Basu U, Yewdell WT, Chaudhuri J, Robbiani DF, Di Noia JM. Casellas R, et al. Nat Rev Immunol. 2016 Mar;16(3):164-76. doi: 10.1038/nri.2016.2. Epub 2016 Feb 22. Nat Rev Immunol. 2016. PMID: 26898111 Free PMC article. Review. - Mechanisms and consequences of sex differences in immune responses.
Dunn SE, Perry WA, Klein SL. Dunn SE, et al. Nat Rev Nephrol. 2024 Jan;20(1):37-55. doi: 10.1038/s41581-023-00787-w. Epub 2023 Nov 22. Nat Rev Nephrol. 2024. PMID: 37993681 Review. - Sex bias in lymphocytes: Implications for autoimmune diseases.
Dodd KC, Menon M. Dodd KC, et al. Front Immunol. 2022 Nov 24;13:945762. doi: 10.3389/fimmu.2022.945762. eCollection 2022. Front Immunol. 2022. PMID: 36505451 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials