The physics behind the larger scale organization of DNA in eukaryotes - PubMed (original) (raw)

The physics behind the larger scale organization of DNA in eukaryotes

Marc Emanuel et al. Phys Biol. 2009.

Abstract

In this paper, we discuss in detail the organization of chromatin during a cell cycle at several levels. We show that current experimental data on large-scale chromatin organization have not yet reached the level of precision to allow for detailed modeling. We speculate in some detail about the possible physics underlying the larger scale chromatin organization.

PubMed Disclaimer

Similar articles

• Structure and dynamics of nucleosomal DNA.
  Muthurajan UM, Park YJ, Edayathumangalam RS, Suto RK, Chakravarthy S, Dyer PN, Luger K. Muthurajan UM, et al. Biopolymers. 2003 Apr;68(4):547-56. doi: 10.1002/bip.10317. Biopolymers. 2003. PMID: 12666179
• Electrostatic interactions with histone tails may bend linker DNA in chromatin.
  Perico A, La Penna G, Arcesi L. Perico A, et al. Biopolymers. 2006 Jan;81(1):20-8. doi: 10.1002/bip.20371. Biopolymers. 2006. PMID: 16167325
• Modeling H3 histone N-terminal tail and linker DNA interactions.
  La Penna G, Furlan S, Perico A. La Penna G, et al. Biopolymers. 2006 Oct 5;83(2):135-47. doi: 10.1002/bip.20538. Biopolymers. 2006. PMID: 16691563
• The controversial 30 nm chromatin fibre.
  Staynov DZ. Staynov DZ. Bioessays. 2008 Oct;30(10):1003-9. doi: 10.1002/bies.20816. Bioessays. 2008. PMID: 18798528 Review.
• Molecular biology. Chromatin higher order folding--wrapping up transcription.
  Horn PJ, Peterson CL. Horn PJ, et al. Science. 2002 Sep 13;297(5588):1824-7. doi: 10.1126/science.1074200. Science. 2002. PMID: 12228709 Review.

Cited by

• Higher-order chromatin structure: bridging physics and biology.
  Fudenberg G, Mirny LA. Fudenberg G, et al. Curr Opin Genet Dev. 2012 Apr;22(2):115-24. doi: 10.1016/j.gde.2012.01.006. Epub 2012 Feb 22. Curr Opin Genet Dev. 2012. PMID: 22360992 Free PMC article. Review.
• Nucleosome conformational variability in solution and in interphase nuclei evidenced by cryo-electron microscopy of vitreous sections.
  Eltsov M, Grewe D, Lemercier N, Frangakis A, Livolant F, Leforestier A. Eltsov M, et al. Nucleic Acids Res. 2018 Sep 28;46(17):9189-9200. doi: 10.1093/nar/gky670. Nucleic Acids Res. 2018. PMID: 30053160 Free PMC article.
• Macromolecule crowding effects on the phase separation of semi-flexible polymer in spherical confined space.
  Wang H, Gu L, Tan R, Ma X, Zhou X, Liu Y. Wang H, et al. J Biol Phys. 2020 Jun;46(2):223-231. doi: 10.1007/s10867-020-09550-9. Epub 2020 Jul 1. J Biol Phys. 2020. PMID: 32613446 Free PMC article.
• Information measure for long-range correlated sequences: the case of the 24 human chromosomes.
  Carbone A. Carbone A. Sci Rep. 2013;3:2721. doi: 10.1038/srep02721. Sci Rep. 2013. PMID: 24056670 Free PMC article.
• Bridging the resolution gap in structural modeling of 3D genome organization.
  Marti-Renom MA, Mirny LA. Marti-Renom MA, et al. PLoS Comput Biol. 2011 Jul;7(7):e1002125. doi: 10.1371/journal.pcbi.1002125. Epub 2011 Jul 14. PLoS Comput Biol. 2011. PMID: 21779160 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • IOP Publishing Ltd.