Transgenic models of tumor development - PubMed (original) (raw)
Review
. 1991 Nov 22;254(5035):1161-7.
doi: 10.1126/science.1957168.
Affiliations
- PMID: 1957168
- DOI: 10.1126/science.1957168
Review
Transgenic models of tumor development
J M Adams et al. Science. 1991.
Abstract
Numerous cancer-prone strains of mice have been created by the introduction of candidate tumor-promoting genes into fertilized eggs. Each transgenic strain is predisposed to develop specific types of tumors, but they usually arise stochastically because of the need for spontaneous mutation of genes that collaborate with the introduced oncogene. These mice are providing insights into the effects of individual oncogenes on cellular proliferation, differentiation, and viability, as well as on oncogene cooperativity. Their predisposed state imposes sensitivity to viral and chemical carcinogenesis, and the mice should prove valuable in tests of potential carcinogens, therapies, and preventive measures.
Similar articles
- Precancer in mice: animal models used to understand, prevent, and treat human precancers.
Cardiff RD, Anver MR, Boivin GP, Bosenberg MW, Maronpot RR, Molinolo AA, Nikitin AY, Rehg JE, Thomas GV, Russell RG, Ward JM. Cardiff RD, et al. Toxicol Pathol. 2006;34(6):699-707. doi: 10.1080/01926230600930129. Toxicol Pathol. 2006. PMID: 17074738 - Oncogene expression in mammary epithelial cells.
Groner B. Groner B. J Cell Biochem. 1992 Jun;49(2):128-36. doi: 10.1002/jcb.240490205. J Cell Biochem. 1992. PMID: 1400620 Review. - Comparative pathology of mammary tumorigenesis in transgenic mice.
Cardiff RD, Munn RJ. Cardiff RD, et al. Cancer Lett. 1995 Mar 23;90(1):13-9. doi: 10.1016/0304-3835(94)03672-6. Cancer Lett. 1995. PMID: 7720037 - Transgenic mice as models for tumorigenesis.
Merlino G. Merlino G. Cancer Invest. 1994;12(2):203-13. doi: 10.3109/07357909409024875. Cancer Invest. 1994. PMID: 8131095 No abstract available. - Use of mouse mammary tumour virus (MMTV)/neu transgenic mice to identify genes collaborating with the c-erbB-2 oncogene in mammary tumour development.
Jolicoeur P, Bouchard L, Guimond A, Ste-Marie M, Hanna Z, Dievart A. Jolicoeur P, et al. Biochem Soc Symp. 1998;63:159-65. Biochem Soc Symp. 1998. PMID: 9513720 Review.
Cited by
- Genetically engineered mouse models for hereditary cancer syndromes.
Biswas K, Mohammed A, Sharan SK, Shoemaker RH. Biswas K, et al. Cancer Sci. 2023 May;114(5):1800-1815. doi: 10.1111/cas.15737. Epub 2023 Feb 14. Cancer Sci. 2023. PMID: 36715493 Free PMC article. Review. - Development of extrahepatic bile ducts and mechanisms of tumorigenesis: Lessons from mouse models.
Tomita H, Hara A. Tomita H, et al. Pathol Int. 2022 Dec;72(12):589-605. doi: 10.1111/pin.13287. Epub 2022 Nov 9. Pathol Int. 2022. PMID: 36349994 Free PMC article. Review. - Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis.
Haraoka Y, Akieda Y, Nagai Y, Mogi C, Ishitani T. Haraoka Y, et al. Nat Commun. 2022 Mar 18;13(1):1417. doi: 10.1038/s41467-022-29061-6. Nat Commun. 2022. PMID: 35304872 Free PMC article. - Model Systems for the Study of Malignant Melanoma.
Gregg RK. Gregg RK. Methods Mol Biol. 2021;2265:1-21. doi: 10.1007/978-1-0716-1205-7_1. Methods Mol Biol. 2021. PMID: 33704702 Review. - Patient Derived Xenografts for Genome-Driven Therapy of Osteosarcoma.
Landuzzi L, Manara MC, Lollini PL, Scotlandi K. Landuzzi L, et al. Cells. 2021 Feb 17;10(2):416. doi: 10.3390/cells10020416. Cells. 2021. PMID: 33671173 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources