MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT - PubMed (original) (raw)
. 2009 Sep 1;8(17):2756-68.
doi: 10.4161/cc.8.17.9387. Epub 2009 Sep 29.
Hong Sun, Hongyue Dai, Ryan M Walsh, Maki Imakura, Janell Schelter, Julja Burchard, Xudong Dai, Aaron N Chang, Robert L Diaz, Joseph R Marszalek, Steven R Bartz, Michael Carleton, Michele A Cleary, Peter S Linsley, Carla Grandori
Affiliations
- PMID: 19652553
- DOI: 10.4161/cc.8.17.9387
Free article
MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT
Zhan Zhang et al. Cell Cycle. 2009.
Free article
Abstract
The hypoxia-inducible factor (HIF) pathway is essential for cell survival under low oxygen and plays an important role in tumor cell homeostasis. We investigated the function of miR-210, the most prominent microRNA upregulated by hypoxia and a direct transcriptional target of HIFs. miR-210 expression was elevated in multiple cancer types and correlated with metastasis of breast and melanoma tumors. miR-210 overexpression in cancer cell lines bypassed hypoxia-induced cell cycle arrest and partially reversed the hypoxic gene expression signature. We identified MNT, a known MYC antagonist, as a miR-210 target. MNT mRNA contains multiple miR-210 binding sites in the 3' UTR and its knockdown phenocopied miR-210 overexpression. Furthermore, loss of MYC abolished miR-210-mediated override of hypoxia-induced cell cycle arrest. Comparison of miR-210 and MYC overexpression with MNT knockdown signatures also indicated that miR-210 triggered a "MYC-like" transcriptional response. Thus, miR-210 influences the hypoxia response in tumor cells through targeting a key transcriptional repressor of the MYC-MAX network.
Comment in
- micRo-manageMeNT of MYC during hypoxia.
Morrish F. Morrish F. Cell Cycle. 2009 Sep 15;8(18):2865. doi: 10.4161/cc.8.18.9722. Cell Cycle. 2009. PMID: 19736515 No abstract available.
Similar articles
- Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radioresistance.
Yang W, Wei J, Guo T, Shen Y, Liu F. Yang W, et al. Exp Cell Res. 2014 Aug 1;326(1):22-35. doi: 10.1016/j.yexcr.2014.05.022. Epub 2014 Jun 12. Exp Cell Res. 2014. PMID: 24930954 - A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression.
Yang H, Li TW, Peng J, Tang X, Ko KS, Xia M, Aller MA. Yang H, et al. Gastroenterology. 2011 Jul;141(1):378-88, 388.e1-4. doi: 10.1053/j.gastro.2011.03.044. Epub 2011 Mar 24. Gastroenterology. 2011. PMID: 21440549 Free PMC article. - Of Myc and Mnt.
Hooker CW, Hurlin PJ. Hooker CW, et al. J Cell Sci. 2006 Jan 15;119(Pt 2):208-16. doi: 10.1242/jcs.02815. J Cell Sci. 2006. PMID: 16410546 Review. - Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the growth of B cell lymphoma.
Li S, He X, Gan Y, Zhang J, Gao F, Lin L, Qiu X, Yu T, Zhang X, Chen P, Tong J, Qian W, Xu Y. Li S, et al. Theranostics. 2021 Jan 19;11(7):3439-3451. doi: 10.7150/thno.53561. eCollection 2021. Theranostics. 2021. PMID: 33537096 Free PMC article. - The activities of MYC, MNT and the MAX-interactome in lymphocyte proliferation and oncogenesis.
Link JM, Hurlin PJ. Link JM, et al. Biochim Biophys Acta. 2015 May;1849(5):554-62. doi: 10.1016/j.bbagrm.2014.04.004. Epub 2014 Apr 13. Biochim Biophys Acta. 2015. PMID: 24731854 Review.
Cited by
- Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma.
Osugi J, Kimura Y, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Muto S, Okabe N, Matsumura Y, Hasegawa T, Yonechi A, Hoshino M, Higuchi M, Shio Y, Suzuki H, Gotoh M. Osugi J, et al. J Oncol. 2015;2015:316745. doi: 10.1155/2015/316745. Epub 2015 Feb 5. J Oncol. 2015. PMID: 25733977 Free PMC article. - Cellular and molecular mechanisms underlying oxygen-dependent radiosensitivity.
Liu C, Lin Q, Yun Z. Liu C, et al. Radiat Res. 2015 May;183(5):487-96. doi: 10.1667/RR13959.1. Epub 2015 May 4. Radiat Res. 2015. PMID: 25938770 Free PMC article. Review. - Hypoxia-inducible factor-1α promotes proliferation of airway smooth muscle cells through miRNA-103-mediated signaling pathway under hypoxia.
Zhang C, Gao J, Zhu S. Zhang C, et al. In Vitro Cell Dev Biol Anim. 2021 Dec;57(10):944-952. doi: 10.1007/s11626-021-00607-0. Epub 2021 Dec 10. In Vitro Cell Dev Biol Anim. 2021. PMID: 34888746 - HypoxamiR regulation and function in ischemic cardiovascular diseases.
Greco S, Gaetano C, Martelli F. Greco S, et al. Antioxid Redox Signal. 2014 Sep 10;21(8):1202-19. doi: 10.1089/ars.2013.5403. Epub 2013 Nov 12. Antioxid Redox Signal. 2014. PMID: 24053126 Free PMC article. Review. - Profiling of a panel of radioresistant prostate cancer cells identifies deregulation of key miRNAs.
McDermott N, Meunier A, Wong S, Buchete V, Marignol L. McDermott N, et al. Clin Transl Radiat Oncol. 2017 Feb 17;2:63-68. doi: 10.1016/j.ctro.2017.01.005. eCollection 2017 Feb. Clin Transl Radiat Oncol. 2017. PMID: 29658003 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources