Chronic kidney disease, hypovitaminosis D, and mortality in the United States - PubMed (original) (raw)

Chronic kidney disease, hypovitaminosis D, and mortality in the United States

Rajnish Mehrotra et al. Kidney Int. 2009 Nov.

Abstract

Low serum 25-hydroxy vitamin D (25OHD) predicts a higher cardiovascular risk in the general population. Because patients with chronic kidney disease are more likely to have low serum 25OHD, we determined the relationship between hypovitaminosis D and death in this group. Analysis was done using a cohort composed of 3011 patients from the Third National Health and Nutrition Examination Survey who had chronic kidney disease but were not on dialysis and who had a mean follow-up of 9 years. In analyses adjusted for demographics, cardiovascular risk factors, serum phosphorus, albumin, hemoglobin, stage of chronic kidney disease, albuminuria, and socioeconomic status, individuals with serum 25OHD levels less than 15 ng/ml had an increased risk for all-cause mortality when compared to those with levels over 30 ng/ml. This significantly higher risk for death with low serum 25OHD was evident in 15 of the 23 subgroups. The higher risk for cardiovascular and non-cardiovascular mortality became statistically nonsignificant on multivariable adjustment. The trend for higher mortality in patients with 25OHD levels 15-30 ng/ml was not statistically significant. Our results indicate there is a graded relationship between serum 25OHD and the risk for death among subjects with chronic kidney disease who are not undergoing dialysis. Randomized, controlled trials are needed to conclusively determine whether vitamin D supplementation reduces mortality.

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Figures

Figure 1

Figure 1. Adjusted hazards ratios for all-cause mortality, adjusted for demographics and cardiovascular risk factors, among different subgroups of the participants in the Third National Health and Nutrition Examination Survey

The risk for all-cause mortality is reported for individuals with serum 25-hydroxy vitamin D levels <15 ng/ml compared with those with levels >30 ng/ml. For each subgroup analysis, data were adjusted for each of the other variables; current smoking, month of year, and family history of cardiovascular disease were included in each subgroup analysis. BMI, body mass index; CHOL, cholesterol; CKD, chronic kidney disease; CRP, _C_-reactive protein; CVD, cardiovascular disease; DM, diabetes mellitus; HDL, high-density lipoprotein.

Figure 2

Figure 2. Adjusted hazards ratios for all-cause mortality, adjusted for demographics and cardiovascular risk factors, among different subgroups of the participants in the Third National Health and Nutrition Examination Survey

The risk for all-cause mortality is reported for individuals with serum 25-hydroxy vitamin D levels 15–30 ng/ml compared with those with levels >30 ng/ml. For each subgroup analysis, data were adjusted for each of the other variables; current smoking, month of year, and family history of cardiovascular disease were included in each subgroup analysis. BMI, body mass index; CHOL, cholesterol; CKD, chronic kidney disease; CRP, _C_-reactive protein; CVD, cardiovascular disease; DM, diabetes mellitus; HDL, high-density lipoprotein.

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References

    1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266–281. - PubMed
    1. Dobnig H, Pilz S, Scharnagl H, et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008;168:1340–1349. - PubMed
    1. Giovannucci E, Liu Y, Hollis BW, et al. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168:1174–1180. - PMC - PubMed
    1. Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117:503–511. - PMC - PubMed
    1. Melamed ML, Michos ED, Post W, et al. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008;168:1629–1637. - PMC - PubMed

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