Clinical impact of aneuploidy on gastric cancer patients - PubMed (original) (raw)

Review

Clinical impact of aneuploidy on gastric cancer patients

Isabel Sánchez-Pérez et al. Clin Transl Oncol. 2009 Aug.

Abstract

Gastric cancer is a leading cause of death worldwide. Nowadays, complete surgical resection and TNM at diagnosis are the main prognostic factors. In spite of this, many patients will have a recurrence after surgery and die within a few months or years. That means that we need more accurate prognostic factors to design specific approaches for individual patients. Chromosome instability is a feature of gastric cancer commonly associated to chromosomal aberrations that leads to major modifications of DNA content globally termed as aneuploidy. In this regard, many authors' opinions diverge regarding the clinical impact of aneuploidy. This review will summarise data on the clinical impact of aneuploidy on clinical practice, the biological mechanisms that underlie chromosomal instability that induces aneuploidy and the relevance of specific chromosomal aneuploidy to cancer biology.

PubMed Disclaimer

Similar articles

• High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer.
  Nishimura S, Oki E, Ando K, Iimori M, Nakaji Y, Nakashima Y, Saeki H, Oda Y, Maehara Y. Nishimura S, et al. Cancer Med. 2017 Jun;6(6):1453-1464. doi: 10.1002/cam4.1090. Epub 2017 May 23. Cancer Med. 2017. PMID: 28544703 Free PMC article.
• ECRG2 disruption leads to centrosome amplification and spindle checkpoint defects contributing chromosome instability.
  Cheng X, Shen Z, Yang J, Lu SH, Cui Y. Cheng X, et al. J Biol Chem. 2008 Feb 29;283(9):5888-98. doi: 10.1074/jbc.M708145200. Epub 2007 Dec 27. J Biol Chem. 2008. PMID: 18162463
• Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype.
  Lentini L, Amato A, Schillaci T, Di Leonardo A. Lentini L, et al. BMC Cancer. 2007 Nov 13;7:212. doi: 10.1186/1471-2407-7-212. BMC Cancer. 2007. PMID: 17999753 Free PMC article.
• Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues.
  Cosenza MR, Krämer A. Cosenza MR, et al. Chromosome Res. 2016 Jan;24(1):105-26. doi: 10.1007/s10577-015-9505-5. Chromosome Res. 2016. PMID: 26645976 Review.
• Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer.
  Lingle WL, Lukasiewicz K, Salisbury JL. Lingle WL, et al. Adv Exp Med Biol. 2005;570:393-421. doi: 10.1007/1-4020-3764-3_14. Adv Exp Med Biol. 2005. PMID: 18727509 Review.

Cited by

• Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells.
  Ge F, Zhang H, Wang DD, Li L, Lin PP. Ge F, et al. Oncotarget. 2015 Sep 29;6(29):27049-64. doi: 10.18632/oncotarget.4819. Oncotarget. 2015. PMID: 26267323 Free PMC article.
• Integrated EpCAM-independent subtraction enrichment and iFISH strategies to detect and classify disseminated and circulating tumors cells.
  Lin PP. Lin PP. Clin Transl Med. 2015 Dec;4(1):38. doi: 10.1186/s40169-015-0081-2. Epub 2015 Dec 30. Clin Transl Med. 2015. PMID: 26718583 Free PMC article.
• Circulating Tumor Cells for Glioma.
  Zhang H, Yuan F, Qi Y, Liu B, Chen Q. Zhang H, et al. Front Oncol. 2021 Mar 10;11:607150. doi: 10.3389/fonc.2021.607150. eCollection 2021. Front Oncol. 2021. PMID: 33777749 Free PMC article. Review.
• Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers.
  Oki E, Hisamatsu Y, Ando K, Saeki H, Kakeji Y, Maehara Y. Oki E, et al. J Gastroenterol. 2012 Apr;47(4):351-8. doi: 10.1007/s00535-012-0565-4. Epub 2012 Mar 9. J Gastroenterol. 2012. PMID: 22402775 Review.
• Genomic and genetic alterations influence the progression of gastric cancer.
  Nobili S, Bruno L, Landini I, Napoli C, Bechi P, Tonelli F, Rubio CA, Mini E, Nesi G. Nobili S, et al. World J Gastroenterol. 2011 Jan 21;17(3):290-9. doi: 10.3748/wjg.v17.i3.290. World J Gastroenterol. 2011. PMID: 21253387 Free PMC article. Review.

References

1. 1. Cancer Cell. 2003 Jan;3(1):51-62 - PubMed
2. 1. World J Gastroenterol. 2007 May 28;13(20):2784-90 - PubMed
3. 1. J Cell Biol. 1998 Jul 13;142(1):1-11 - PubMed
4. 1. Curr Biol. 2006 Sep 5;16(17):1705-10 - PubMed
5. 1. Oncology. 1996 May-Jun;53(3):182-91 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Medical

  • MedlinePlus Health Information