Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo - PubMed (original) (raw)
Comparative Study
. 2009 Sep 1;183(5):3229-36.
doi: 10.4049/jimmunol.0804277. Epub 2009 Aug 10.
Marius Cornitescu, Natalia Zietara, Marcin Łyszkiewicz, Nelson Gekara, Jadwiga Jabłónska, Frank Edenhofer, Klaus Rajewsky, Dunja Bruder, Martin Hafner, Peter Staeheli, Siegfried Weiss
Affiliations
- PMID: 19667093
- DOI: 10.4049/jimmunol.0804277
Comparative Study
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo
Stefan Lienenklaus et al. J Immunol. 2009.
Abstract
Type I IFN is a major player in innate and adaptive immune responses. Besides, it is involved in organogenesis and tumor development. Generally, IFN responses are amplified by an autocrine loop with IFN-beta as the priming cytokine. However, due to the lack of sensitive detection systems, where and how type I IFN is produced in vivo is still poorly understood. In this study, we describe a luciferase reporter mouse, which allows tracking of IFN-beta gene induction in vivo. Using this reporter mouse, we reveal strong tissue-specific induction of IFN-beta following infection with influenza or La Crosse virus. Importantly, this reporter mouse also allowed us to visualize that IFN-beta is expressed constitutively in several tissues. As suggested before, low amounts of constitutively produced IFN might maintain immune cells in an activated state ready for a timely response to pathogens. Interestingly, thymic epithelial cells were the major source of IFN-beta under noninflammatory conditions. This relatively high constitutive expression was controlled by the NF Aire and might influence induction of tolerance or T cell development.
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