Toll-like receptors and innate immunity - PubMed (original) (raw)
Review
. 2009 Oct 30;388(4):621-5.
doi: 10.1016/j.bbrc.2009.08.062. Epub 2009 Aug 15.
Affiliations
- PMID: 19686699
- DOI: 10.1016/j.bbrc.2009.08.062
Review
Toll-like receptors and innate immunity
Himanshu Kumar et al. Biochem Biophys Res Commun. 2009.
Abstract
Toll-like receptors (TLRs) are evolutionarily conserved innate receptors expressed in various immune and non-immune cells of the mammalian host. TLRs play a crucial role in defending against pathogenic microbial infection through the induction of inflammatory cytokines and type I interferons. Furthermore, TLRs also play roles in shaping pathogen-specific humoral and cellular adaptive immune responses. In this review, we describe the recent advances in pathogen recognition by TLRs and TLR signaling.
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