Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding - PubMed (original) (raw)
. 2009 Sep;50(9):1464-70.
doi: 10.2967/jnumed.109.064360. Epub 2009 Aug 18.
Affiliations
- PMID: 19690025
- DOI: 10.2967/jnumed.109.064360
Free article
Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding
Nelleke Tolboom et al. J Nucl Med. 2009 Sep.
Free article
Abstract
The purpose of this study was to investigate the potential relationships between cerebrospinal fluid (CSF) measurements of beta-amyloid-1-42 (Abeta(1-42)) and total tau to (11)C-Pittsburgh compound B ((11)C-PiB) and 2-(1-{6-[(2-(18)F-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) malononitrile ((18)F-FDDNP) binding as measured using PET.
Methods: A total of 37 subjects were included, consisting of 15 patients with Alzheimer disease (AD), 12 patients with mild cognitive impairment, and 10 healthy controls. All subjects underwent a lumbar puncture and PET using both (11)C-PiB and (18)F-FDDNP. For both PET tracers, parametric images of binding potential were generated. Potential associations of CSF levels of Abeta(1-42) and tau with (11)C-PiB and (18)F-FDDNP binding were assessed using Pearson correlation coefficients and linear regression analyses.
Results: For both global (11)C-PiB and (18)F-FDDNP binding, significant correlations with CSF levels of Abeta(1-42) (r = -0.72 and -0.37, respectively) and tau (r = 0.58 and 0.56, respectively) were found across groups (all P < 0.001, except P < 0.05 for correlation between (18)F-FDDNP and Abeta(1-42)). Linear regression analyses showed that, adjusted for regional volume, age, sex, and diagnosis, global (11)C-PiB uptake had an inverse association with Abeta(1-42) CSF levels (standardized beta = -0.50, P < 0.001), whereas there was a positive association between global (18)F-FDDNP binding and tau CSF levels (standardized beta = 0.62, P < 0.01).
Conclusion: The good agreement between these 2 different types of biomarkers (i.e., CSF and PET) provides converging evidence for their validity. The inverse association between (11)C-PiB and CSF tau Abeta(1-42) confirms that (11)C-PiB measures amyloid load in the brain. The positive association between (18)F-FDDNP and CSF tau suggests that at least part of the specific signal of (18)F-FDDNP in AD patients is due to tangle formation.
Similar articles
- Concordance and Diagnostic Accuracy of [11C]PIB PET and Cerebrospinal Fluid Biomarkers in a Sample of Patients with Mild Cognitive Impairment and Alzheimer's Disease.
Leuzy A, Carter SF, Chiotis K, Almkvist O, Wall A, Nordberg A. Leuzy A, et al. J Alzheimers Dis. 2015;45(4):1077-88. doi: 10.3233/JAD-142952. J Alzheimers Dis. 2015. PMID: 25649653 - Dementia mimicking Alzheimer's disease Owing to a tau mutation: CSF and PET findings.
Tolboom N, Koedam EL, Schott JM, Yaqub M, Blankenstein MA, Barkhof F, Pijnenburg YA, Lammertsma AA, Scheltens P, van Berckel BN. Tolboom N, et al. Alzheimer Dis Assoc Disord. 2010 Jul-Sep;24(3):303-7. doi: 10.1097/WAD.0b013e3181cf35ec. Alzheimer Dis Assoc Disord. 2010. PMID: 20683187 - Concordance between cerebrospinal fluid biomarkers and [11C]PIB PET in a memory clinic cohort.
Zwan M, van Harten A, Ossenkoppele R, Bouwman F, Teunissen C, Adriaanse S, Lammertsma A, Scheltens P, van Berckel B, van der Flier W. Zwan M, et al. J Alzheimers Dis. 2014;41(3):801-7. doi: 10.3233/JAD-132561. J Alzheimers Dis. 2014. PMID: 24705549 - Amyloid-β and τ biomarkers in Parkinson's disease-dementia.
Buongiorno M, Compta Y, Martí MJ. Buongiorno M, et al. J Neurol Sci. 2011 Nov 15;310(1-2):25-30. doi: 10.1016/j.jns.2011.06.046. Epub 2011 Jul 20. J Neurol Sci. 2011. PMID: 21764078 Review. - Concordance between brain 18F-FDG PET and cerebrospinal fluid biomarkers in diagnosing Alzheimer's disease.
Rubí S, Noguera A, Tarongí S, Oporto M, García A, Vico H, Espino A, Picado MJ, Mas A, Peña C, Amer G. Rubí S, et al. Rev Esp Med Nucl Imagen Mol (Engl Ed). 2018 Jan-Feb;37(1):3-8. doi: 10.1016/j.remn.2017.05.003. Epub 2017 Jun 20. Rev Esp Med Nucl Imagen Mol (Engl Ed). 2018. PMID: 28645685 Review. English, Spanish.
Cited by
- Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease.
Toledo JB, Bjerke M, Da X, Landau SM, Foster NL, Jagust W, Jack C Jr, Weiner M, Davatzikos C, Shaw LM, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative Investigators. Toledo JB, et al. JAMA Neurol. 2015 May;72(5):571-81. doi: 10.1001/jamaneurol.2014.4829. JAMA Neurol. 2015. PMID: 25822737 Free PMC article. - Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease.
Vandenberghe R, Adamczuk K, Dupont P, Laere KV, Chételat G. Vandenberghe R, et al. Neuroimage Clin. 2013 Apr 6;2:497-511. doi: 10.1016/j.nicl.2013.03.014. eCollection 2013. Neuroimage Clin. 2013. PMID: 24179802 Free PMC article. Review. - Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease.
Perrin RJ, Craig-Schapiro R, Malone JP, Shah AR, Gilmore P, Davis AE, Roe CM, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, Kaye JA, Morris JC, Holtzman DM, Townsend RR, Fagan AM. Perrin RJ, et al. PLoS One. 2011 Jan 12;6(1):e16032. doi: 10.1371/journal.pone.0016032. PLoS One. 2011. PMID: 21264269 Free PMC article. - Fluid Biomarkers in Clinical Trials of Alzheimer's Disease Therapeutics.
Ritter A, Cummings J. Ritter A, et al. Front Neurol. 2015 Aug 31;6:186. doi: 10.3389/fneur.2015.00186. eCollection 2015. Front Neurol. 2015. PMID: 26379620 Free PMC article. Review. - A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aβ42 cutoff with concordance to amyloid positron emission tomography imaging.
Mo Y, Stromswold J, Wilson K, Holder D, Sur C, Laterza O, Savage MJ, Struyk A, Scheltens P, Teunissen CE, Burke J, Macaulay SL, Bråthen G, Sando SB, White LR, Weiss C, Cowes A, Bush MM, DeSilva G, Darby DG, Rainey-Smith SR, Surls J, Sagini E, Tanen M, Altman A, Luthman J, Egan MF. Mo Y, et al. Alzheimers Dement (Amst). 2017 Mar 6;6:201-209. doi: 10.1016/j.dadm.2017.02.004. eCollection 2017. Alzheimers Dement (Amst). 2017. PMID: 28349119 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical