Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter - PubMed (original) (raw)

. 1990 May 24;345(6273):346-7.

doi: 10.1038/345346a0.

Affiliations

• PMID: 1971425
• DOI: 10.1038/345346a0

Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter

H Bult et al. Nature. 1990.

Abstract

Inhibitory non-adrenergic non-cholinergic (NANC) nerves are thought to be important in the autonomic innervation of the gastrointestinal tract and other organ systems. The nature of their neurotransmitter is still debated. Speculation that nitric oxide (NO), formed from L-arginine in neuronal structures and other cells, could act as a neurotransmitter, is not yet supported by demonstration of its release upon nerve stimulation. Using a superfusion bioassay, we report the release of a vasorelaxant factor upon stimulation of the NANC nerves in the canine ileocolonic junction. Several pieces of evidence, including the selectivity of the bioassay tissues, chemical instability, inactivation by superoxide anion and haemoglobin, inhibition by NG-nitro-L-arginine (L-NNA) and potentiation by L-arginine all indicated that NO accounted for the biological activity of this transferable NANC factor.

PubMed Disclaimer

Comment in

• Neurotransmitter identity doubt.
  Ignarro LJ, Bush PA, Buga GM, Rajfer J. Ignarro LJ, et al. Nature. 1990 Sep 13;347(6289):131-2. doi: 10.1038/347131b0. Nature. 1990. PMID: 1975643 No abstract available.

Similar articles

• Bioassay of nitric oxide released upon stimulation of non-adrenergic non-cholinergic nerves in the canine ileocolonic junction.
  Boeckxstaens GE, Pelckmans PA, Ruytjens IF, Bult H, De Man JG, Herman AG, Van Maercke YM. Boeckxstaens GE, et al. Br J Pharmacol. 1991 May;103(1):1085-91. doi: 10.1111/j.1476-5381.1991.tb12304.x. Br J Pharmacol. 1991. PMID: 1908732 Free PMC article.
• Bioassay and pharmacological characterization of the nitrergic neurotransmitter.
  Boeckxstaens GE, De Man JG, De Winter BY, Moreels TG, Herman AG, Pelckmans PA. Boeckxstaens GE, et al. Arch Int Pharmacodyn Ther. 1995 Jan-Feb;329(1):11-26. Arch Int Pharmacodyn Ther. 1995. PMID: 7639612
• Non-adrenergic non-cholinergic relaxation mediated by nitric oxide in the canine ileocolonic junction.
  Boeckxstaens GE, Pelckmans PA, Bult H, De Man JG, Herman AG, Van Maercke YM. Boeckxstaens GE, et al. Eur J Pharmacol. 1990 Nov 6;190(1-2):239-46. doi: 10.1016/0014-2999(90)94132-h. Eur J Pharmacol. 1990. PMID: 1981752
• [Biological role of metabolic pathways from L-arginine to nitric oxide].
  Zembowicz A. Zembowicz A. Folia Med Cracov. 1992;33(1-4):103-16. Folia Med Cracov. 1992. PMID: 1342993 Review. Polish.
• Novel autonomic neurotransmitters and upper gastrointestinal function.
  McKirdy HC. McKirdy HC. Pharmacol Ther. 1988;38(3):429-52. doi: 10.1016/0163-7258(88)90013-7. Pharmacol Ther. 1988. PMID: 2904154 Review.

Cited by

• Evaluation of the causal effects of blood metabolites on irritable bowel syndrome: Mendelian randomization.
  Zeng Y, Liu H, Pei Z, Li R, Liu Z, Liao C. Zeng Y, et al. BMC Gastroenterol. 2024 Jan 5;24(1):19. doi: 10.1186/s12876-023-03111-9. BMC Gastroenterol. 2024. PMID: 38182988 Free PMC article.
• 6-OHDA-Induced Changes in Colonic Segment Contractility in the Rat Model of Parkinson's Disease.
  Murillo MDP, Johansson E, Bryntesson V, Aronsson P, Tobin G, Winder M, Carlsson T. Murillo MDP, et al. Gastroenterol Res Pract. 2023 Jan 27;2023:9090524. doi: 10.1155/2023/9090524. eCollection 2023. Gastroenterol Res Pract. 2023. PMID: 36743531 Free PMC article.
• Repurposing nitric oxide donating drugs in cancer therapy through immune modulation.
  Li CY, Anuraga G, Chang CP, Weng TY, Hsu HP, Ta HDK, Su PF, Chiu PH, Yang SJ, Chen FW, Ye PH, Wang CY, Lai MD. Li CY, et al. J Exp Clin Cancer Res. 2023 Jan 14;42(1):22. doi: 10.1186/s13046-022-02590-0. J Exp Clin Cancer Res. 2023. PMID: 36639681 Free PMC article.
• Exacerbation-prone pediatric asthma is associated with arginine, lysine, and methionine pathway alterations.
  Cottrill KA, Stephenson ST, Mohammad AF, Kim SO, McCarty NA, Kamaleswaran R, Fitzpatrick AM, Chandler JD. Cottrill KA, et al. J Allergy Clin Immunol. 2023 Jan;151(1):118-127.e10. doi: 10.1016/j.jaci.2022.07.027. Epub 2022 Sep 9. J Allergy Clin Immunol. 2023. PMID: 36096204 Free PMC article.
• Inhibiting Fatty Acid Amide Hydrolase Ameliorates Enteropathy in Diabetic Mice: A Cannabinoid 1 Receptor Mediated Mechanism.
  Thakur V, Bashashati M, Enriquez J, Chattopadhyay M. Thakur V, et al. Vet Sci. 2022 Jul 16;9(7):364. doi: 10.3390/vetsci9070364. Vet Sci. 2022. PMID: 35878381 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations