Diabetes mellitus type II as a risk factor for depression: a lower than expected risk in a general practice setting - PubMed (original) (raw)

Diabetes mellitus type II as a risk factor for depression: a lower than expected risk in a general practice setting

S Aarts et al. Eur J Epidemiol. 2009.

Abstract

The aim of the present study was to determine whether a diagnosis of diabetes mellitus (DM) in a primary setting is associated with an increased risk of subsequent depression. A retrospective cohort design was used based on the Registration Network Family Practice (RNH) database. Patients diagnosed with diabetes mellitus at or after the age of 40 and who were diagnosed between 01-01-1980 and 01-01-2007 (N = 6,140), were compared with age-matched controls from a reference group (N = 18,416) without a history of diabetes. Both groups were followed for an emerging first diagnosis of depression (and/or depressive feelings) until January 1, 2008. 2.0% of the people diagnosed with diabetes mellitus developed a depressive disorder, compared to 1.6% of the reference group. After statistical correction for confounding factors diabetes mellitus was associated with an increased risk of developing subsequent depression (HR 1.26; 95% CI: 1.12-1.42) and/or depressive feelings (HR 1.33; 95% CI: 1.18-1.46). After statistical adjustment practice identification code, age and depression preceding diabetes, were significantly related to a diagnosis of depression. Patients with diabetes mellitus are more likely to develop subsequent depression than persons without a history of diabetes. Results from this large longitudinal study based on a general practice population indicate that this association is weaker than previously found in cross-sectional research using self-report surveys. Several explanations for this dissimilarity are discussed

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Figures

Fig. 1

Fig. 1

Survival curve corrected for age, practice identification code and a diagnosis of depression preceding DM

Fig. 2

Fig. 2

Survival curve corrected for age, practice identification code and a diagnosis of depression preceding DM

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References

    1. Penninx BW, Beekman AT, Ormel J, Kriegsman DM, Boeke AJ, van Eijk JT, et al. Psychological status among elderly people with chronic diseases: does type of disease play a part? J Psychosom Res. 1996;40(5):521–534. doi: 10.1016/0022-3999(95)00620-6. - DOI - PubMed
    1. Barnard KD, Skinner TC, Peveler R. The prevalence of co-morbid depression in adults with type 1 diabetes: systematic literature review. Diabet Med. 2006;23(4):445–448. doi: 10.1111/j.1464-5491.2006.01814.x. - DOI - PubMed
    1. Li C, Ford ES, Strine TW, Mokdad AH. Prevalence of depression among US adults with diabetes: findings from the 2006 behavioral risk factor surveillance system. Diabetes Care. 2008;31(1):105–107. doi: 10.2337/dc07-1154. - DOI - PubMed
    1. Ludman EJ, Katon W, Russo J, Von Korff M, Simon G, Ciechanowski P, et al. Depression and diabetes symptom burden. Gen Hosp Psychiatry. 2004;26(6):430–436. doi: 10.1016/j.genhosppsych.2004.08.010. - DOI - PubMed
    1. Anderson RJ, Clouse RE, Freedland KE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes. A meta-analysis. Diabetes Care. 2001;24(6):1069–1078. doi: 10.2337/diacare.24.6.1069. - DOI - PubMed

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