Paraneoplastic cerebellar degeneration mimicking acute post-infectious cerebellitis - PubMed (original) (raw)

Case Reports

Paraneoplastic cerebellar degeneration mimicking acute post-infectious cerebellitis

Yuval Karmon et al. Cerebellum. 2009 Dec.

Abstract

Acute cerebellitis is a monophasic non-progressive encephalitis restricted to the cerebellum, while paraneoplastic cerebellar degeneration is a subacute progressive disorder, which may either accompany or herald Hodgkin's disease. In the present report, we describe a young man with clinical and laboratory features of acute post-infectious cerebellitis in whom the progressive relapsing course subsequently led to the diagnosis of Hodgkin's disease. Dynamic changes observed on repeated MRIs during the protracted clinical course imply the presence of early active inflammation and subsequent neuronal atrophy.

PubMed Disclaimer

Similar articles

• Metabotropic glutamate receptor type 1 autoantibody-associated cerebellitis: a primary autoimmune disease?
  Marignier R, Chenevier F, Rogemond V, Sillevis Smitt P, Renoux C, Cavillon G, Androdias G, Vukusic S, Graus F, Honnorat J, Confavreux C. Marignier R, et al. Arch Neurol. 2010 May;67(5):627-30. doi: 10.1001/archneurol.2010.51. Arch Neurol. 2010. PMID: 20457964
• Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma.
  Ypma PF, Wijermans PW, Koppen H, Sillevis Smitt PA. Ypma PF, et al. Neth J Med. 2006 Jul-Aug;64(7):243-7. Neth J Med. 2006. PMID: 16929086
• Unusual MRI abnormalities in anti-Yo positive "pure" paraneoplastic cerebellar degeneration.
  McHugh JC, Tubridy N, Collins CD, Hutchinson M. McHugh JC, et al. J Neurol. 2008 Jan;255(1):138-9. doi: 10.1007/s00415-007-0682-9. Epub 2007 Nov 14. J Neurol. 2008. PMID: 17994310 No abstract available.
• Hodgkin's lymphoma associated with paraneoplastic cerebellar degeneration in children: a case report and review of the literature.
  Gungor S, Kilic B, Arslan M, Ozgen U. Gungor S, et al. Childs Nerv Syst. 2017 Mar;33(3):509-512. doi: 10.1007/s00381-016-3284-y. Epub 2016 Oct 29. Childs Nerv Syst. 2017. PMID: 27796550 Review.
• Fulminant cerebellitis: a fatal, clinically isolated syndrome.
  Kamate M, Chetal V, Hattiholi V. Kamate M, et al. Pediatr Neurol. 2009 Sep;41(3):220-2. doi: 10.1016/j.pediatrneurol.2009.03.018. Pediatr Neurol. 2009. PMID: 19664542 Review.

Cited by

• Movement disorders in paraneoplastic and autoimmune disease.
  Panzer J, Dalmau J. Panzer J, et al. Curr Opin Neurol. 2011 Aug;24(4):346-53. doi: 10.1097/WCO.0b013e328347b307. Curr Opin Neurol. 2011. PMID: 21577108 Free PMC article. Review.
• Past, present and future therapeutics for cerebellar ataxias.
  Marmolino D, Manto M. Marmolino D, et al. Curr Neuropharmacol. 2010 Mar;8(1):41-61. doi: 10.2174/157015910790909476. Curr Neuropharmacol. 2010. PMID: 20808545 Free PMC article.
• Update on Paraneoplastic Cerebellar Degeneration.
  Loehrer PA, Zieger L, Simon OJ. Loehrer PA, et al. Brain Sci. 2021 Oct 26;11(11):1414. doi: 10.3390/brainsci11111414. Brain Sci. 2021. PMID: 34827413 Free PMC article. Review.

References

1. 1. J Neurol Neurosurg Psychiatry. 2004 Aug;75(8):1135-40 - PubMed
2. 1. Brain. 2000 Jul;123 ( Pt 7):1481-94 - PubMed
3. 1. N Engl J Med. 2000 Jan 6;342(1):21-7 - PubMed
4. 1. Neurology. 1992 Oct;42(10):1938-43 - PubMed
5. 1. J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):529-30 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Medical

  • MedlinePlus Health Information