Diverse regulatory pathways for IgA synthesis in the gut - PubMed (original) (raw)

Review

doi: 10.1038/mi.2009.107. Epub 2009 Sep 9.

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Review

Diverse regulatory pathways for IgA synthesis in the gut

K Suzuki et al. Mucosal Immunol. 2009 Nov.

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Abstract

Immunoglobulin (Ig) A is the most abundant antibody isotype in mucosal secretions. In this study we summarize recent advances in our understanding of the compartments and mechanisms of intestinal IgA synthesis. We discuss the pathways leading to the generation of IgA(+) B cells in follicular and extra-follicular structures, by T-cell-dependent and T-cell-independent mechanisms.

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