Flexible spike timing of layer 5 neurons during dynamic beta oscillation shifts in rat prefrontal cortex - PubMed (original) (raw)

A, example field potential traces from L3 before (‘con’, top) and after (‘CCh’, middle) application of 25 μ

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carbachol, and after application of carbachol and 1 μ

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zolpidem (‘Zolp’, bottom). Raw traces are shown in grey, bandpass (5–25 Hz) filtered traces are shown in black. B, frequency analysis of the recordings in A. Power spectra showed a decrease in oscillation frequency after zolpidem application. C, oscillation power in L3 (left) and L6 (right) is not changed after zolpidem application (L3: _n_= 4, _P_= 0.34. L6: _n_= 4, _P_= 0.96). D, oscillation frequency in both L3 and L6 is decreased after zolpidem application (L3: _n_= 4, _P_= 0.03. L6: _n_= 3, _P_= 0.01). Note that this is combined data from L1–L3 and L5–L6 micro-slices, and intact brain slices. E, example field potential traces from L3 before (‘con’, top) and after (‘CCh’, middle top) application of 25 μ

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carbachol, after application of carbachol and 200 μ

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cyclothiazide (‘CTZ’, middle bottom), and after wash-out of cyclothiazide (‘wash’, bottom). Raw traces are shown in grey, bandpass (5–25 Hz) filtered traces are shown in black. F, frequency analysis of the recordings in E. G, oscillation power in L3 (left) and L6 (right) is not changed after cyclothiazide application (L3: _n_= 8, _P_= 0.54. L6: _n_= 4, _P_= 0.08). H, oscillation frequency in L3 and L6 is not changed after cyclothiazide application (L3: _n_= 8, _P_= 0.79. L6: _n_= 4, _P_= 0.76). Note that these are data from intact brain slices.