Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1 - PubMed (original) (raw)

. 1990 Oct 11;347(6293):528-33.

doi: 10.1038/347528a0.

Affiliations

• PMID: 1977085
• DOI: 10.1038/347528a0

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

S Li et al. Nature. 1990.

Abstract

Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.

PubMed Disclaimer

Similar articles

• Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.
  Sornson MW, Wu W, Dasen JS, Flynn SE, Norman DJ, O'Connell SM, Gukovsky I, Carrière C, Ryan AK, Miller AP, Zuo L, Gleiberman AS, Andersen B, Beamer WG, Rosenfeld MG. Sornson MW, et al. Nature. 1996 Nov 28;384(6607):327-33. doi: 10.1038/384327a0. Nature. 1996. PMID: 8934515
• Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth.
  Lin C, Lin SC, Chang CP, Rosenfeld MG. Lin C, et al. Nature. 1992 Dec 24-31;360(6406):765-8. doi: 10.1038/360765a0. Nature. 1992. PMID: 1334535
• The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation.
  Camper SA, Saunders TL, Katz RW, Reeves RH. Camper SA, et al. Genomics. 1990 Nov;8(3):586-90. doi: 10.1016/0888-7543(90)90050-5. Genomics. 1990. PMID: 1981057
• Pituitary transcription factors: from congenital deficiencies to gene therapy.
  Quentien MH, Barlier A, Franc JL, Pellegrini I, Brue T, Enjalbert A. Quentien MH, et al. J Neuroendocrinol. 2006 Sep;18(9):633-42. doi: 10.1111/j.1365-2826.2006.01461.x. J Neuroendocrinol. 2006. PMID: 16879162 Review.
• Transcriptional control of cell phenotypes in the neuroendocrine system.
  Rosenfeld MG, Bach I, Erkman L, Li P, Lin C, Lin S, McEvilly R, Ryan A, Rhodes S, Schonnemann M, Scully K. Rosenfeld MG, et al. Recent Prog Horm Res. 1996;51:217-38; discussion 238-9. Recent Prog Horm Res. 1996. PMID: 8701080 Review.

Cited by

• Multi-omic profiling of pituitary thyrotropic cells and progenitors.
  Daly AZ, Dudley LA, Peel MT, Liebhaber SA, Parker SCJ, Camper SA. Daly AZ, et al. BMC Biol. 2021 Apr 15;19(1):76. doi: 10.1186/s12915-021-01009-0. BMC Biol. 2021. PMID: 33858413 Free PMC article.
• A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones.
  Odle AK, Allensworth-James ML, Akhter N, Syed M, Haney AC, MacNicol M, MacNicol AM, Childs GV. Odle AK, et al. Endocrinology. 2016 Oct;157(10):3958-3971. doi: 10.1210/en.2016-1472. Epub 2016 Aug 29. Endocrinology. 2016. PMID: 27571135 Free PMC article.
• Genetic regulation of murine pituitary development.
  Rizzoti K. Rizzoti K. J Mol Endocrinol. 2015 Apr;54(2):R55-73. doi: 10.1530/JME-14-0237. Epub 2015 Jan 13. J Mol Endocrinol. 2015. PMID: 25587054 Free PMC article. Review.
• The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish.
  Quiroz Y, Lopez M, Mavropoulos A, Motte P, Martial JA, Hammerschmidt M, Muller M. Quiroz Y, et al. Mol Endocrinol. 2012 Jun;26(6):1014-27. doi: 10.1210/me.2011-1319. Epub 2012 Apr 27. Mol Endocrinol. 2012. PMID: 22543271 Free PMC article.
• Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4.
  Collins LL, Lee YF, Heinlein CA, Liu NC, Chen YT, Shyr CR, Meshul CK, Uno H, Platt KA, Chang C. Collins LL, et al. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15058-63. doi: 10.1073/pnas.0405700101. Epub 2004 Oct 11. Proc Natl Acad Sci U S A. 2004. PMID: 15477591 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)