Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex - PubMed (original) (raw)

Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex

M G Blanton et al. Proc Natl Acad Sci U S A. 1990 Oct.

Abstract

Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels on neurons in the cortical plate. Throughout cortical development, these channels exhibit voltage-dependent Mg2+ blockade and are antagonized by D-2-amino-5-phosphonovaleric acid, a selective NMDA receptor antagonist. The activation in situ of these nonsynaptic NMDA channels demonstrates a potential physiological substrate for control of early neuronal differentiation.

PubMed Disclaimer

References

    1. J Physiol. 1973 Dec;235(3):655-91 - PubMed
    1. J Morphol. 1968 Jun;125(2):219-51 - PubMed
    1. Brain Res. 1983 Apr 11;265(1):21-30 - PubMed
    1. J Comp Neurol. 1983 Apr 20;215(4):437-52 - PubMed
    1. J Physiol. 1983 Jan;334:33-46 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources