Gut commensal Lactobacillus reuteri 100-23 stimulates an immunoregulatory response - PubMed (original) (raw)

doi: 10.1038/icb.2009.71. Epub 2009 Sep 29.

Affiliations

• PMID: 19786979
• DOI: 10.1038/icb.2009.71

Gut commensal Lactobacillus reuteri 100-23 stimulates an immunoregulatory response

Megan Livingston et al. Immunol Cell Biol. 2010 Jan.

Abstract

Lactobacillus reuteri 100-23 is a bacterial commensal of the gastrointestinal tract of mice. Previous studies have shown that colonization of the murine gut by this strain stimulates small-bowel enterocytes to produce proinflammatory cytokines. This is associated with a mild, transitory inflammatory response 6 days after inoculation of formerly Lactobacillus-free animals. The inflammation subsides by 21 days after colonization, although lactobacilli continue to be present in the bowel. To determine the immunological mechanisms that underpin tolerance to bowel commensals, we investigated cytokine responses of dendritic cells and T cells after exposure to cells of L. reuteri 100-23. Interleukin-10 (IL-10), IL-2 and transforming growth factor-beta (TGF-beta) concentrations in supernatants of cultured immune cells, as well as the results of proliferative assays of mesenteric lymph node (MLN) cells and quantification of Foxp3-positive cells in MLN and spleen, indicated that L. reuteri 100-23 stimulated the development of an increased number of regulatory T cells.

PubMed Disclaimer

Similar articles

• Beneficial effects of Lactobacillus reuteri 6475 on bone density in male mice is dependent on lymphocytes.
  Collins FL, Rios-Arce ND, Schepper JD, Jones AD, Schaefer L, Britton RA, McCabe LR, Parameswaran N. Collins FL, et al. Sci Rep. 2019 Oct 11;9(1):14708. doi: 10.1038/s41598-019-51293-8. Sci Rep. 2019. PMID: 31605025 Free PMC article.
• Immunomodulation of dendritic cells by Lactobacillus reuteri surface components and metabolites.
  Engevik MA, Ruan W, Esparza M, Fultz R, Shi Z, Engevik KA, Engevik AC, Ihekweazu FD, Visuthranukul C, Venable S, Schady DA, Versalovic J. Engevik MA, et al. Physiol Rep. 2021 Jan;9(2):e14719. doi: 10.14814/phy2.14719. Physiol Rep. 2021. PMID: 33463911 Free PMC article.
• Lactobacillus acidophilus and Lactobacillus reuteri modulate cytokine responses in gnotobiotic pigs infected with human rotavirus.
  Azevedo MS, Zhang W, Wen K, Gonzalez AM, Saif LJ, Yousef AE, Yuan L. Azevedo MS, et al. Benef Microbes. 2012 Mar 1;3(1):33-42. doi: 10.3920/BM2011.0041. Benef Microbes. 2012. PMID: 22348907 Free PMC article.
• Influence of Lactobacillus reuteri L26 Biocenol™ on immune response against porcine circovirus type 2 infection in germ-free mice.
  Karaffová V, Csank T, Mudroňová D, Király J, Revajová V, Gancarčíková S, Nemcová R, Pistl J, Vilček Š, Levkut M. Karaffová V, et al. Benef Microbes. 2017 May 30;8(3):367-378. doi: 10.3920/BM2016.0114. Epub 2017 May 15. Benef Microbes. 2017. PMID: 28504566
• Microbiota and Probiotics: The Role of Limosilactobacillus Reuteri in Diverticulitis.
  Piccioni A, Franza L, Vaccaro V, Saviano A, Zanza C, Candelli M, Covino M, Franceschi F, Ojetti V. Piccioni A, et al. Medicina (Kaunas). 2021 Aug 5;57(8):802. doi: 10.3390/medicina57080802. Medicina (Kaunas). 2021. PMID: 34441008 Free PMC article. Review.

Cited by

• Deciphering the Potential of Probiotics in Vaccines.
  Xu C, Aqib AI, Fatima M, Muneer S, Zaheer T, Peng S, Ibrahim EH, Li K. Xu C, et al. Vaccines (Basel). 2024 Jun 26;12(7):711. doi: 10.3390/vaccines12070711. Vaccines (Basel). 2024. PMID: 39066349 Free PMC article. Review.
• Local and Systemic Effects of Bioactive Food Ingredients: Is There a Role for Functional Foods to Prime the Gut for Resilience?
  Jacquier EF, van de Wouw M, Nekrasov E, Contractor N, Kassis A, Marcu D. Jacquier EF, et al. Foods. 2024 Feb 28;13(5):739. doi: 10.3390/foods13050739. Foods. 2024. PMID: 38472851 Free PMC article. Review.
• The importance of the timing of microbial signals for perinatal immune system development.
  Archer D, Perez-Muñoz ME, Tollenaar S, Veniamin S, Cheng CC, Richard C, Barreda DR, Field CJ, Walter J. Archer D, et al. Microbiome Res Rep. 2023 Apr 15;2(2):11. doi: 10.20517/mrr.2023.03. eCollection 2023. Microbiome Res Rep. 2023. PMID: 38047281 Free PMC article.
• Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis.
  Yang Y, Wang Y, Zhao L, Wang F, Li M, Wang Q, Luo H, Zhao Q, Zeng J, Zhao Y, Du F, Chen Y, Shen J, Wei S, Xiao Z, Wu X. Yang Y, et al. Chin Herb Med. 2023 Mar 28;15(2):181-200. doi: 10.1016/j.chmed.2023.03.003. eCollection 2023 Apr. Chin Herb Med. 2023. PMID: 37265772 Free PMC article. Review.
• The synergetic potential of Lactobacillus delbrueckii and Lactobacillus fermentum probiotics in alleviating the outcome of acute toxoplasmosis in mice.
  Almallah TM, Khedr SI, El Nouby KA, Younis SS, Elazeem MA, Elmehy DA. Almallah TM, et al. Parasitol Res. 2023 Apr;122(4):927-937. doi: 10.1007/s00436-023-07787-6. Epub 2023 Feb 14. Parasitol Res. 2023. PMID: 36786888 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database