Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia - PubMed (original) (raw)

doi: 10.1038/npp.2009.140.

Thomas Frodl, Derek Morris, Ilaria Spoletini, Dara M Cannon, Andrea Cherubini, Carlo Caltagirone, Paola Bossù, Colm McDonald, Michael Gill, Aiden P Corvin, Gianfranco Spalletta

Affiliations

Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia

Gary Donohoe et al. Neuropsychopharmacology. 2010 Jan.

Abstract

A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry, whole-volume analysis revealed significantly reduced GMVs in both the right dorsolateral prefrontal and left occipital cortex, corresponding to the behavioral findings of impaired spatial working memory and EEG findings of impaired visual processing already reported. These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased.

PubMed Disclaimer

Figures

Figure 1

Figure 1

Differences between patient carriers and non-carriers of the dysbindin-risk haplotype. Risk carriers show significantly smaller gray matter volumes in (a) left occipital cortex and (b) right dorsolateral prefrontal cortex (FWE corrected).

Similar articles

Cited by

References

    1. Allen brain atlas 2009. Allen Institute for Brain Science. . http://www.brain-map.org Accessed on 15 June 2009.
    1. Ashburner J, Friston KJ. Unified segmentation. Neuroimage. 2005;26:839–851. - PubMed
    1. Bach Cuadra M, Cammoun L, Butz T, Cuisenaire O, Thiran JP. Comparison and validation of tissue modelization and statistical classification methods in T1-weighted MR brain images. IEEE Trans Med Imaging. 2005;24:1548–1565. - PubMed
    1. Bray NJ, Preece A, Williams NM, Moskvina V, Buckland PR, Owen MJ, et al. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Hum Mol Genet. 2005;14:1947–1954. - PubMed
    1. Burdick KE, Lencz T, Funke B, Finn CT, Szeszko PR, Kane JM, et al. Genetic variation in DTNBP1 influences general cognitive ability. Hum Mol Genet. 2006;15:1563–1568. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources