The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily - PubMed (original) (raw)

. 1990 Dec;348(6303):693-9.

doi: 10.1038/348693a0.

Affiliations

• PMID: 1979659
• DOI: 10.1038/348693a0

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

R V Aroian et al. Nature. 1990 Dec.

Abstract

The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.

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Comment in

• Ras proteins. Some signal developments.
  Bourne HR, Wrischnik L, Kenyon C. Bourne HR, et al. Nature. 1990 Dec 20-27;348(6303):678-9. doi: 10.1038/348678a0. Nature. 1990. PMID: 2175395 No abstract available.

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