Manic depressive illness not linked to factor IX region in an independent series of pedigrees - PubMed (original) (raw)
Manic depressive illness not linked to factor IX region in an independent series of pedigrees
P V Gejman et al. Genomics. 1990 Dec.
Abstract
We studied seven informative kindreds segregating for manic depressive illness (MDI), consistent with X-chromosome transmission of the trait (families do not show affective disease in both a father and a son), using markers mapped to the region of Xq27-Xq28. The lod scores were consistently below -2 in the region extending from about 10 cM centromeric from the Factor IX locus (F9) to the colorblindness region. This study does not replicate previous reports of linkage of MDI to Factor IX (Xq27) and colorblindness region (Xq28) chromosomal markers in other kindreds.
Similar articles
- Polymorphic DNA marker on X chromosome and manic depression.
Mendlewicz J, Simon P, Sevy S, Charon F, Brocas H, Legros S, Vassart G. Mendlewicz J, et al. Lancet. 1987 May 30;1(8544):1230-2. doi: 10.1016/s0140-6736(87)92685-7. Lancet. 1987. PMID: 2884369 - Manic-depressive illness and linkage reanalysis in the Xq27-Xq28 region of chromosome X.
Mendelbaum K, Sevy S, Souery D, Papadimitriou GN, De Bruyn A, Raeymaekers P, Van Broeckhoven C, Mendlewicz J. Mendelbaum K, et al. Neuropsychobiology. 1995;31(2):58-63. doi: 10.1159/000119173. Neuropsychobiology. 1995. PMID: 7760986 - X-chromosome markers and manic-depressive illness. Rejection of linkage to Xq28 in nine bipolar pedigrees.
Berrettini WH, Goldin LR, Gelernter J, Gejman PV, Gershon ES, Detera-Wadleigh S. Berrettini WH, et al. Arch Gen Psychiatry. 1990 Apr;47(4):366-73. doi: 10.1001/archpsyc.1990.01810160066010. Arch Gen Psychiatry. 1990. PMID: 2322087 - X-linkage in bipolar affective illness. Perspectives on genetic heterogeneity, pedigree analysis and the X-chromosome map.
Baron M, Rainer JD, Risch N. Baron M, et al. J Affect Disord. 1981 Jun;3(2):141-57. doi: 10.1016/0165-0327(81)90039-2. J Affect Disord. 1981. PMID: 6454708 Review. - Minireview: Molecular genetics in affective illness.
Mendlewicz J, Sevy S, Mendelbaum K. Mendlewicz J, et al. Life Sci. 1993;52(3):231-42. doi: 10.1016/0024-3205(93)90214-n. Life Sci. 1993. PMID: 8423707 Review.
Cited by
- Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.
Detera-Wadleigh SD, Badner JA, Goldin LR, Berrettini WH, Sanders AR, Rollins DY, Turner G, Moses T, Haerian H, Muniec D, Nurnberger JI Jr, Gershon ES. Detera-Wadleigh SD, et al. Am J Hum Genet. 1996 Jun;58(6):1279-85. Am J Hum Genet. 1996. PMID: 8651306 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Miscellaneous