Histopathology of non-alcoholic fatty liver disease - PubMed (original) (raw)
Review
Histopathology of non-alcoholic fatty liver disease
Elizabeth M Brunt. Clin Liver Dis. 2009 Nov.
Abstract
Current imaging methodologies can detect steatosis with increasing accuracy but cannot detect inflammation or pre-cirrhotic fibrosis or remodeling of the liver parenchyma. Imaging also cannot assess types or localization of hepatic steatosis. With the increased use of rodents to study NAFLD/NASH, careful analysis or reading highlights the fact that liver tissue evaluations reported in many of the popular animal models of NAFLD/NASH often do not imitate many of the significant aspects of the human disease, despite similar terminology applied by investigators. This review will focus on the findings in human disease.
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