Amphipathic helices and membrane curvature - PubMed (original) (raw)
Review
. 2010 May 3;584(9):1840-7.
doi: 10.1016/j.febslet.2009.10.022. Epub 2009 Oct 20.
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- PMID: 19837069
- DOI: 10.1016/j.febslet.2009.10.022
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Review
Amphipathic helices and membrane curvature
Guillaume Drin et al. FEBS Lett. 2010.
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Abstract
Numerous data have been collected on lipid-binding amphipathic helices involved in membrane-remodeling machineries and vesicular transport. Here we describe how, with regard to lipid composition, the physicochemical features of some amphipathic helices explain their ability to recognize membrane curvature or to participate in membrane remodeling. We propose that sensing highly-curved membranes requires that the polar and hydrophobic faces of the helix do not cooperate in lipid binding. A more detailed description of the interaction between amphipathic helices and lipids is however needed; notably to explain how new helices contribute to detection of modest changes in curvature or even negative curvature.
Copyright 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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