Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer - PubMed (original) (raw)

Review

Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

Yogeshkumar Malam et al. Trends Pharmacol Sci. 2009 Nov.

Abstract

Nanoscale drug delivery systems using liposomes and nanoparticles are emerging technologies for the rational delivery of chemotherapeutic drugs in the treatment of cancer. Their use offers improved pharmacokinetic properties, controlled and sustained release of drugs and, more importantly, lower systemic toxicity. The commercial availability of liposomal Doxil and albumin-nanoparticle-based Abraxane has focused attention on this innovative and exciting field. Recent advances in liposome technology offer better treatment of multidrug-resistant cancers and lower cardiotoxicity. Nanoparticles offer increased precision in chemotherapeutic targeting of prostate cancer and new avenues for the treatment of breast cancer. Here we review current knowledge on the two technologies and their potential applications to cancer treatment.

PubMed Disclaimer

Similar articles

• Nanoparticles for drug delivery in cancer treatment.
  Haley B, Frenkel E. Haley B, et al. Urol Oncol. 2008 Jan-Feb;26(1):57-64. doi: 10.1016/j.urolonc.2007.03.015. Urol Oncol. 2008. PMID: 18190833 Review.
• Nanoparticle technologies for cancer therapy.
  Alexis F, Pridgen EM, Langer R, Farokhzad OC. Alexis F, et al. Handb Exp Pharmacol. 2010;(197):55-86. doi: 10.1007/978-3-642-00477-3_2. Handb Exp Pharmacol. 2010. PMID: 20217526 Review.
• Nanoparticles for delivery of chemotherapeutic agents to tumors.
  Vijayaraghavalu S, Raghavan D, Labhasetwar V. Vijayaraghavalu S, et al. Curr Opin Investig Drugs. 2007 Jun;8(6):477-84. Curr Opin Investig Drugs. 2007. PMID: 17621878 Review.
• [Development of antituberculous drugs: current status and future prospects].
  Tomioka H, Namba K. Tomioka H, et al. Kekkaku. 2006 Dec;81(12):753-74. Kekkaku. 2006. PMID: 17240921 Review. Japanese.
• [Progress in the study of drug delivery system based on nanoparticles to overcome multi-drug resistance].
  Chen JN, Shen Q, Li SS. Chen JN, et al. Yao Xue Xue Bao. 2009 Apr;44(4):333-7. Yao Xue Xue Bao. 2009. PMID: 19545047 Review. Chinese.

Cited by

• Intelligent design of multifunctional lipid-coated nanoparticle platforms for cancer therapy.
  Ramishetti S, Huang L. Ramishetti S, et al. Ther Deliv. 2012 Dec;3(12):1429-45. doi: 10.4155/tde.12.127. Ther Deliv. 2012. PMID: 23323560 Free PMC article. Review.
• Enhancing radiotherapy for melanoma: the promise of high-Z metal nanoparticles in radiosensitization.
  Bemidinezhad A, Radmehr S, Moosaei N, Efati Z, Kesharwani P, Sahebkar A. Bemidinezhad A, et al. Nanomedicine (Lond). 2024;19(28):2391-2411. doi: 10.1080/17435889.2024.2403325. Epub 2024 Oct 9. Nanomedicine (Lond). 2024. PMID: 39382020 Review.
• Carrier Systems for Advanced Drug Delivery: Improving Drug Solubility/Bioavailability and Administration Routes.
  Losada-Barreiro S, Celik S, Sezgin-Bayindir Z, Bravo-Fernández S, Bravo-Díaz C. Losada-Barreiro S, et al. Pharmaceutics. 2024 Jun 25;16(7):852. doi: 10.3390/pharmaceutics16070852. Pharmaceutics. 2024. PMID: 39065549 Free PMC article. Review.
• Integration of biosensors and drug delivery technologies for early detection and chronic management of illness.
  Ngoepe M, Choonara YE, Tyagi C, Tomar LK, du Toit LC, Kumar P, Ndesendo VM, Pillay V. Ngoepe M, et al. Sensors (Basel). 2013 Jun 14;13(6):7680-713. doi: 10.3390/s130607680. Sensors (Basel). 2013. PMID: 23771157 Free PMC article. Review.
• Building Cell Selectivity into CPP-Mediated Strategies.
  Martín I, Teixidó M, Giralt E. Martín I, et al. Pharmaceuticals (Basel). 2010 May 14;3(5):1456-1490. doi: 10.3390/ph3051456. Pharmaceuticals (Basel). 2010. PMID: 27713313 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database