Altered translation of the matrix genes in Niigata and Yamagata neurovirulent measles virus strains - PubMed (original) (raw)
Altered translation of the matrix genes in Niigata and Yamagata neurovirulent measles virus strains
M Ayata et al. Virology. 1991 Jan.
Abstract
Niigata and Yamagata strains measles virus were isolated from subacute sclerosing panencephalitis patients. These viruses were defective in virion production and expression of matrix (M) protein. The Niigata M protein-coding frame was interrupted by an in-frame termination codon, whereas the Yamagata M gene lacked the normal translational initiation codon. These mutations prevented translation of a normal M protein. However, RNA derived from the cloned Niigata and Yamagata M genes was translatable in vitro into low levels of aberrant proteins that reacted with M-specific antiserum. These proteins were also translated from poly(A)+ RNA from cells infected by Niigata and Yamagata virus strains. The aberrant M protein of Niigata virus was initiated at a downstream AUG codon created by a second mutation. The Yamagata M gene produced two aberrant proteins: one initiated mainly in vitro at an ACG codon, and a second species initiated at a downstream site both in vitro and in vivo. These results define the abnormal translational functions of the Niigata and Yamagata M genes, and further implicate the involvement of M protein defects in chronic central nervous system infections by measles virus.
Similar articles
- Role of biased hypermutation in evolution of subacute sclerosing panencephalitis virus from progenitor acute measles virus.
Wong TC, Ayata M, Ueda S, Hirano A. Wong TC, et al. J Virol. 1991 May;65(5):2191-9. doi: 10.1128/JVI.65.5.2191-2199.1991. J Virol. 1991. PMID: 2016756 Free PMC article. - Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.
Suryanarayana K, Baczko K, ter Meulen V, Wagner RR. Suryanarayana K, et al. J Virol. 1994 Mar;68(3):1532-43. doi: 10.1128/JVI.68.3.1532-1543.1994. J Virol. 1994. PMID: 8107216 Free PMC article. - The measles virus matrix gene and gene product defined by in vitro and in vivo expression.
Wong TC, Wipf G, Hirano A. Wong TC, et al. Virology. 1987 Apr;157(2):497-508. doi: 10.1016/0042-6822(87)90292-3. Virology. 1987. PMID: 3824908 - Generation and properties of measles virus mutations typically associated with subacute sclerosing panencephalitis.
Billeter MA, Cattaneo R, Spielhofer P, Kaelin K, Huber M, Schmid A, Baczko K, ter Meulen V. Billeter MA, et al. Ann N Y Acad Sci. 1994 Jun 6;724:367-77. doi: 10.1111/j.1749-6632.1994.tb38934.x. Ann N Y Acad Sci. 1994. PMID: 8030963 Review.
Cited by
- Brain tropism acquisition: The spatial dynamics and evolution of a measles virus collective infectious unit that drove lethal subacute sclerosing panencephalitis.
Yousaf I, Hannon WW, Donohue RC, Pfaller CK, Yadav K, Dikdan RJ, Tyagi S, Schroeder DC, Shieh WJ, Rota PA, Feder AF, Cattaneo R. Yousaf I, et al. PLoS Pathog. 2023 Dec 21;19(12):e1011817. doi: 10.1371/journal.ppat.1011817. eCollection 2023 Dec. PLoS Pathog. 2023. PMID: 38127684 Free PMC article. - A Novel Peptide Derived from the Fusion Protein Heptad Repeat Inhibits Replication of Subacute Sclerosing Panencephalitis Virus In Vitro and In Vivo.
Watanabe M, Hashimoto K, Abe Y, Kodama EN, Nabika R, Oishi S, Ohara S, Sato M, Kawasaki Y, Fujii N, Hosoya M. Watanabe M, et al. PLoS One. 2016 Sep 9;11(9):e0162823. doi: 10.1371/journal.pone.0162823. eCollection 2016. PLoS One. 2016. PMID: 27612283 Free PMC article. - Characteristics of viruses derived from nude mice with persistent measles virus infection.
Abe Y, Hashimoto K, Watanabe M, Ohara S, Sato M, Kawasaki Y, Hashimoto Y, Hosoya M. Abe Y, et al. J Virol. 2013 Apr;87(8):4170-5. doi: 10.1128/JVI.03117-12. Epub 2013 Jan 23. J Virol. 2013. PMID: 23345518 Free PMC article. - Mutations affecting transcriptional termination in the p gene end of subacute sclerosing panencephalitis viruses.
Ayata M, Komase K, Shingai M, Matsunaga I, Katayama Y, Ogura H. Ayata M, et al. J Virol. 2002 Dec;76(24):13062-8. doi: 10.1128/jvi.76.24.13062-13068.2002. J Virol. 2002. PMID: 12438633 Free PMC article.