Animal models for atrial fibrillation: clinical insights and scientific opportunities - PubMed (original) (raw)
Review
Animal models for atrial fibrillation: clinical insights and scientific opportunities
Kunihiro Nishida et al. Europace. 2010 Feb.
Abstract
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. A variety of animal models have been used to study the pathophysiology of AF, including molecular basis, ion-current determinants, anatomical features, and macroscopic mechanisms. In addition, animal models play a key role in the development of new therapeutic approaches, whether drug-based, molecular therapeutics, or device-related. This article discusses the various types of animal models that have been used for AF research, reviews the principle mechanisms governing atrial arrhythmias in each model, and provides some guidelines for model selection for various purposes.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical