Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice - PubMed (original) (raw)
Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice
Tathiana A Alvarenga et al. Addict Biol. 2010 Jan.
Abstract
We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4-Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins.
Similar articles
- Sleep loss and acute drug abuse can induce DNA damage in multiple organs of mice.
Alvarenga TA, Ribeiro DA, Araujo P, Hirotsu C, Mazaro-Costa R, Costa JL, Battisti MC, Tufik S, Andersen ML. Alvarenga TA, et al. Hum Exp Toxicol. 2011 Sep;30(9):1275-81. doi: 10.1177/0960327110388535. Epub 2010 Nov 11. Hum Exp Toxicol. 2011. PMID: 21071548 - Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: influence of ambient temperature.
Carvalho M, Carvalho F, Remião F, de Lourdes Pereira M, Pires-das-Neves R, de Lourdes Bastos M. Carvalho M, et al. Arch Toxicol. 2002 Apr;76(3):166-72. doi: 10.1007/s00204-002-0324-z. Epub 2002 Mar 1. Arch Toxicol. 2002. PMID: 11967622 - Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective.
Thomasius R, Zapletalova P, Petersen K, Buchert R, Andresen B, Wartberg L, Nebeling B, Schmoldt A. Thomasius R, et al. J Psychopharmacol. 2006 Mar;20(2):211-25. doi: 10.1177/0269881106059486. J Psychopharmacol. 2006. PMID: 16510479 Review. - The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview.
Gouzoulis-Mayfrank E, Daumann J. Gouzoulis-Mayfrank E, et al. J Psychopharmacol. 2006 Mar;20(2):188-93. doi: 10.1177/0269881106059939. J Psychopharmacol. 2006. PMID: 16510477 Review.
Cited by
- Novel Psychoactive Phenethylamines: Impact on Genetic Material.
Cocchi V, Gasperini S, Hrelia P, Tirri M, Marti M, Lenzi M. Cocchi V, et al. Int J Mol Sci. 2020 Dec 17;21(24):9616. doi: 10.3390/ijms21249616. Int J Mol Sci. 2020. PMID: 33348640 Free PMC article. - In Situ Detection of Complex DNA Damage Using Microscopy: A Rough Road Ahead.
Nikitaki Z, Pariset E, Sudar D, Costes SV, Georgakilas AG. Nikitaki Z, et al. Cancers (Basel). 2020 Nov 6;12(11):3288. doi: 10.3390/cancers12113288. Cancers (Basel). 2020. PMID: 33172046 Free PMC article. Review. - Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage.
Song BJ, Moon KH, Upreti VV, Eddington ND, Lee IJ. Song BJ, et al. Curr Pharm Biotechnol. 2010 Aug;11(5):434-43. doi: 10.2174/138920110791591436. Curr Pharm Biotechnol. 2010. PMID: 20420575 Free PMC article. Review. - Genotoxicity and repair capability of Mus musculus DNA following the oral exposure to Tramadol.
Ali T, Rafiq M, Samee Mubarik M, Zahoor K, Asad F, Yaqoob S, Ahmad S, Qamar S. Ali T, et al. Saudi J Biol Sci. 2020 Jan;27(1):12-17. doi: 10.1016/j.sjbs.2019.03.008. Epub 2019 Mar 26. Saudi J Biol Sci. 2020. PMID: 31889811 Free PMC article. - Activation of proline metabolism maintains ATP levels during cocaine-induced polyADP-ribosylation.
Dash S, Dash C, Pandhare J. Dash S, et al. Amino Acids. 2021 Dec;53(12):1903-1915. doi: 10.1007/s00726-021-03065-w. Epub 2021 Aug 21. Amino Acids. 2021. PMID: 34417893 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical