Comparative genomic and phylogeographic analysis of Mycobacterium leprae - PubMed (original) (raw)

Comparative Study

. 2009 Dec;41(12):1282-9.

doi: 10.1038/ng.477. Epub 2009 Nov 1.

Nadine Honoré, Thierry Garnier, Nora Zidane, Diana Sherafi, Alberto Paniz-Mondolfi, Masanori Matsuoka, G Michael Taylor, Helen D Donoghue, Abi Bouwman, Simon Mays, Claire Watson, Diana Lockwood, Ali Khamesipour, Yahya Dowlati, Shen Jianping, Thomas H Rea, Lucio Vera-Cabrera, Mariane M Stefani, Sayera Banu, Murdo Macdonald, Bishwa Raj Sapkota, John S Spencer, Jérôme Thomas, Keith Harshman, Pushpendra Singh, Philippe Busso, Alexandre Gattiker, Jacques Rougemont, Patrick J Brennan, Stewart T Cole

Affiliations

• PMID: 19881526
• DOI: 10.1038/ng.477

Free article

Comparative Study

Comparative genomic and phylogeographic analysis of Mycobacterium leprae

Marc Monot et al. Nat Genet. 2009 Dec.

Free article

Erratum in

• Nat Genet. 2010 Apr;42(4):361. Khamispour, Ali [corrected to Khamesipour, Ali]

Abstract

Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38x coverage) and NHDP63 (46x coverage) from Thailand and the United States, respectively. Whole-genome comparisons with the previously sequenced TN strain from India revealed that the four strains share 99.995% sequence identity and differ only in 215 polymorphic sites, mainly SNPs, and by 5 pseudogenes. Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world. The 16 SNP subtypes showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy.

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Comment in

• Putting leprosy on the map.
  Maiden MC. Maiden MC. Nat Genet. 2009 Dec;41(12):1264-6. doi: 10.1038/ng1209-1264. Nat Genet. 2009. PMID: 19935762 Free PMC article. No abstract available.

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