Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis - PubMed (original) (raw)
. 1991 Feb 15;251(4995):788-91.
doi: 10.1126/science.1990440.
Affiliations
- PMID: 1990440
- DOI: 10.1126/science.1990440
Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
M I Cybulsky et al. Science. 1991.
Abstract
An inducible rabbit endothelial adhesion molecule that is selective for mononuclear leukocytes has been identified. This adhesion protein was expressed on the surface of activated cultured endothelium in two forms, 118 and 98 kilodaltons, the amino-terminal sequence of each being highly homologous to human VCAM-1. In dietary hypercholesterolemic and Watanabe heritable hyperlipidemic rabbit models of atherosclerosis, this adhesion molecule was found to be expressed in a localized fashion by aortic endothelium that overlies early foam cell lesions. This lesion-localized expression suggests a potential endothelium-dependent mechanism for mononuclear leukocyte recruitment during atherogenesis and may provide a molecular marker for early atherosclerosis.
Similar articles
- An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium.
Li H, Cybulsky MI, Gimbrone MA Jr, Libby P. Li H, et al. Arterioscler Thromb. 1993 Feb;13(2):197-204. doi: 10.1161/01.atv.13.2.197. Arterioscler Thromb. 1993. PMID: 7678986 - Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis.
Gimbrone MA Jr. Gimbrone MA Jr. Am J Cardiol. 1995 Feb 23;75(6):67B-70B. doi: 10.1016/0002-9149(95)80016-l. Am J Cardiol. 1995. PMID: 7532351 Review. - Endothelial-leukocyte adhesive interactions in inflammatory diseases.
Munro JM. Munro JM. Eur Heart J. 1993 Dec;14 Suppl K:72-7. Eur Heart J. 1993. PMID: 7510638 Review.
Cited by
- Comparative Analysis of Atherogenic Lipoproteins L5 and Lp(a) in Atherosclerotic Cardiovascular Disease.
Akyol O, Yang CY, Woodside DG, Chiang HH, Chen CH, Gotto AM. Akyol O, et al. Curr Atheroscler Rep. 2024 Jul;26(7):317-329. doi: 10.1007/s11883-024-01209-3. Epub 2024 May 16. Curr Atheroscler Rep. 2024. PMID: 38753254 Free PMC article. Review. - Century of Milestones and Breakthroughs Related to the Immune Mechanisms of Atherosclerosis.
Mallat Z, Tedgui A. Mallat Z, et al. Arterioscler Thromb Vasc Biol. 2024 May;44(5):1002-1006. doi: 10.1161/ATVBAHA.124.319397. Epub 2024 Apr 24. Arterioscler Thromb Vasc Biol. 2024. PMID: 38657035 Free PMC article. Review. No abstract available. - Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis.
Manzo OL, Nour J, Sasset L, Marino A, Rubinelli L, Palikhe S, Smimmo M, Hu Y, Bucci MR, Borczuk A, Elemento O, Freed JK, Norata GD, Di Lorenzo A. Manzo OL, et al. Circ Res. 2024 Apr 12;134(8):990-1005. doi: 10.1161/CIRCRESAHA.123.323826. Epub 2024 Mar 8. Circ Res. 2024. PMID: 38456287 - Relationship between pattern reversal visual evoked potential P100 wave latency and dysfunctional HDL in patients with multiple sclerosis subjected to an optic neuritis attack: A case-control study.
Vural G, Gumusyayla S, Karakoyunlu Eren F, Barakli S, Demir Unal E, Neselioglu S, Erel O. Vural G, et al. Medicine (Baltimore). 2024 Feb 9;103(6):e37115. doi: 10.1097/MD.0000000000037115. Medicine (Baltimore). 2024. PMID: 38335440 Free PMC article. - Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE-/- Mice.
Ren J, Liu J, Zhang J, Hu X, Cui Y, Wei X, Ma Y, Li X, Zhao Y. Ren J, et al. Int J Mol Sci. 2023 Dec 23;25(1):244. doi: 10.3390/ijms25010244. Int J Mol Sci. 2023. PMID: 38203413 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous