Post-synaptic potentials recorded from afferent nerve fibres of the posterior semicircular canal in the frog - PubMed (original) (raw)
Post-synaptic potentials recorded from afferent nerve fibres of the posterior semicircular canal in the frog
M L Rossi et al. Brain Res. 1977.
Abstract
Glass microelectrode recordings were made from single fibres of the posterior ampullary nerve in the isolated labyrinth of the frog (Rana esculenta). Potentials were recorded both at rest and during rotatory stimulation of the canal. At rest, the tracings revealed an intense background of small, largely summated potentials (0.5-10 mV amplitude, 3-6 msec duration), which underlay the discharge of spikes in all the impaled units. The frequency of the subthreshold events was related to the frequency of the propagated spikes, the latter ranging from 0 to 40/sec. Stimulation modulated the frequency of both spikes and subthreshold potentials, whose summation during excitation led to a positive shift of the fibre membrane potential. The small potentials proved to be dependent on Ca2+ and Mg2+ levels in the bath. Antidromic-stimulation of the posterior ampullary nerve indicated that the observed events do not represent an artifact due to extracellular field interference related to spike activity in the neighbouring fibres. Tetrodotoxin (10(-7)-10(-6) g/ml) applied externally to the preparation or previously perfused through the frog vessels abolishes the propagated spikes but left unaffected the small potentials which, even under drug treatment, were normally modulated by the stimulus. The subthreshold potentials thus appear to be EPSPs generated at the cyto-neural junction between the hair cells and the endings of the ampullary nerve fibres.
Similar articles
- Analysis of pre- and postsynaptic activity in the frog semicircular canal following ototoxic insult: differential recovery of background and evoked afferent activity.
Russo G, Calzi D, Gioglio L, Botta L, Polimeni MR, Zucca G, Martini M, Contini D, Fesce R, Rossi ML, Prigioni I. Russo G, et al. Neuroscience. 2009 Nov 10;163(4):1327-39. doi: 10.1016/j.neuroscience.2009.07.026. Epub 2009 Jul 18. Neuroscience. 2009. PMID: 19619619 - [Effects of temperature on postsynaptic potentials at the cyto-neural junctions of the frog semicircular canal].
Zucca G, Valli P, Botta L, Casella C. Zucca G, et al. Boll Soc Ital Biol Sper. 1983 Jul 30;59(7):1010-5. Boll Soc Ital Biol Sper. 1983. PMID: 6605152 Italian. - The origin of slow potentials in semicircular canals of the frog.
Valli P, Zucca G. Valli P, et al. Acta Otolaryngol. 1976 May-Jun;81(5-6):395-405. doi: 10.3109/00016487609107493. Acta Otolaryngol. 1976. PMID: 1084096 - Rapid structural changes in nerve fibers and cells associated with their excitation processes.
Tasaki I. Tasaki I. Jpn J Physiol. 1999 Apr;49(2):125-38. doi: 10.2170/jjphysiol.49.125. Jpn J Physiol. 1999. PMID: 10393347 Review.
Cited by
- Resting discharge patterns of macular primary afferents in otoconia-deficient mice.
Jones TA, Jones SM, Hoffman LF. Jones TA, et al. J Assoc Res Otolaryngol. 2008 Dec;9(4):490-505. doi: 10.1007/s10162-008-0132-0. Epub 2008 Jul 27. J Assoc Res Otolaryngol. 2008. PMID: 18661184 Free PMC article. - Spontaneous discharge patterns in cochlear spiral ganglion cells before the onset of hearing in cats.
Jones TA, Leake PA, Snyder RL, Stakhovskaya O, Bonham B. Jones TA, et al. J Neurophysiol. 2007 Oct;98(4):1898-908. doi: 10.1152/jn.00472.2007. Epub 2007 Aug 8. J Neurophysiol. 2007. PMID: 17686914 Free PMC article. - Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cells.
Edmonds BW, Gregory FD, Schweizer FE. Edmonds BW, et al. J Physiol. 2004 Oct 15;560(Pt 2):439-50. doi: 10.1113/jphysiol.2004.066035. Epub 2004 Aug 12. J Physiol. 2004. PMID: 15308677 Free PMC article. - Quantal nature of synaptic transmission at the cytoneural junction in the frog labyrinth.
Rossi ML, Martini M, Pelucchi B, Fesce R. Rossi ML, et al. J Physiol. 1994 Jul 1;478 ( Pt 1)(Pt 1):17-35. doi: 10.1113/jphysiol.1994.sp020227. J Physiol. 1994. PMID: 7965832 Free PMC article. - A stochastic afterhyperpolarization model of repetitive activity in vestibular afferents.
Smith CE, Goldberg JM. Smith CE, et al. Biol Cybern. 1986;54(1):41-51. doi: 10.1007/BF00337114. Biol Cybern. 1986. PMID: 3487348
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous