Naive T cell homeostasis: from awareness of space to a sense of place - PubMed (original) (raw)

Review

doi: 10.1038/nri2657.

Affiliations

Review

Naive T cell homeostasis: from awareness of space to a sense of place

Kensuke Takada et al. Nat Rev Immunol. 2009 Dec.

Abstract

The peripheral naive T cell pool is fairly stable in number, diversity and functional competence in the absence of vigorous immune responses. However, this apparent tranquility is not an intrinsic property of T cells but involves continuous tuning of the T cell pool composition by homeostatic signals. In the past decade, studies have revealed that naive T cells rely on combinatorial signals from self-peptide-MHC complexes and interleukin-7 for their physical and functional maintenance. Competition for these factors dictates T cell 'space'. In addition, recent studies show that these and other homeostatic factors are offered to T cells on stromal cell networks, which also serve to guide T cell trafficking in secondary lymphoid organs. Such findings suggest the importance of 'place' in the perception and integration of homeostatic cues for the maintenance and functional tuning of the naive T cell pool.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Exp Med. 2004 Nov 1;200(9):1189-95 - PubMed
    1. J Exp Med. 2000 Jan 17;191(2):355-64 - PubMed
    1. Immunity. 1999 Mar;10(3):367-76 - PubMed
    1. J Immunol. 2008 Jun 1;180(11):7265-75 - PubMed
    1. J Immunol. 2001 Dec 15;167(12):6869-76 - PubMed

Publication types

MeSH terms

LinkOut - more resources