Tissue-mediated control of immunopathology in coeliac disease - PubMed (original) (raw)
Review
doi: 10.1038/nri2670.
Affiliations
- PMID: 19935805
- DOI: 10.1038/nri2670
Review
Tissue-mediated control of immunopathology in coeliac disease
Bana Jabri et al. Nat Rev Immunol. 2009 Dec.
Abstract
Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation--induced either by infectious agents or by gluten--is crucial for activating T cells and eliciting their tissue-destructive effector functions.
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References
- Nature. 1995 Jul 13;376(6536):177-80 - PubMed
- J Exp Med. 2000 Feb 21;191(4):603-12 - PubMed
- Nat Immunol. 2009 Oct;10(10):1096-101 - PubMed
- Gastroenterology. 2003 Sep;125(3):730-45 - PubMed
- Immunity. 2004 Jun;20(6):757-67 - PubMed
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