Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective - PubMed (original) (raw)
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doi: 10.1038/nri2660.
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- PMID: 19935807
- DOI: 10.1038/nri2660
Review
Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective
Casey T Weaver et al. Nat Rev Immunol. 2009 Dec.
Abstract
The origins of the adaptive immune system and the basis for its unique association with vertebrate species have been a source of considerable speculation. In light of recent advances in our understanding of the developmental and functional links between the induced regulatory T cell and T helper 17 cell lineages, and their specialized relationship to the gut, we speculate that the co-evolution of these adaptive immune pathways might have given primitive vertebrates a means to benefit from the diversification of their commensal microbiota.
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