The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients - PubMed (original) (raw)
The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients
M V Aksenova et al. FEBS Lett. 1991.
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Abstract
The content of casein kinase 2 is considerably decreased in ribosome-free extracts of the frontal cortex of schizophrenic and Alzheimer's disease patients in comparison to normal brains as has been demonstrated by means of immunoblotting. The activity of casein kinase 2 towards endogenous substrates and casein is also diminished in the cases of mental pathologies examined. This phenomenon may explain the well-known aberrations in the phosphorylation of structural proteins of human brain which are intrinsic for the mental diseases.
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