Regional obesity and risk of cardiovascular disease; the Framingham Study - PubMed (original) (raw)
Regional obesity and risk of cardiovascular disease; the Framingham Study
W B Kannel et al. J Clin Epidemiol. 1991.
Abstract
Risk of cardiovascular events was determined over 24 years of surveillance in relation to general adiposity reflected by relative weight and by regional obesity estimated by skinfolds and waist girth per inch of height. Upper quintile values of relative weight, subscapular skinfolds and waist girth were each associated with increased risks of cardiovascular disease in both sexes. Risk of total cardiovascular events increased with the degree of regional, central or abdominal obesity. Mortality from cardiovascular disease was also increased. Increased relative weight and central obesity were both associated with increased risk factors including cholesterol, blood pressure, glucose and uric acid. Changes in weight were mirrored by changes in risk factors with linear trends over a 15 lb range of weight fluctuations. Subscapular skinfold and the ratio of subscapular-to-triceps skinfold, measures of central obesity, were in either sex also associated with an increased probability of coronary attacks in particular. The subscapular skinfold contributed to CHD risk independent of body mass index (BMI). Multivariate analyses taking all the risk factors into account indicate an independent effect of abdominal obesity on stroke, cardiac failure and cardiovascular and all-cause mortality in men. In women, only the subscapular-to-triceps skinfold ratio independently contributes to CHD, cardiovascular and all cause mortality. Regional obesity appears to be an independent contributor to cardiovascular disease at a given level of general adiposity, its effect only partially mediated through promotion of other known risk factors. These data suggest that cardiovascular disease is as closely linked to abdominal as to general adiposity.
Similar articles
- Subscapular and triceps skinfold thicknesses, body mass index and cardiovascular risk factors in a cohort of middle-aged employed men.
Birmingham B, Dyer AR, Shekelle RB, Stamler J. Birmingham B, et al. J Clin Epidemiol. 1993 Mar;46(3):289-302. doi: 10.1016/0895-4356(93)90077-e. J Clin Epidemiol. 1993. PMID: 8455054 - Hazards of obesity--the Framingham experience.
Higgins M, Kannel W, Garrison R, Pinsky J, Stokes J 3rd. Higgins M, et al. Acta Med Scand Suppl. 1988;723:23-36. doi: 10.1111/j.0954-6820.1987.tb05925.x. Acta Med Scand Suppl. 1988. PMID: 3164971 - Central obesity: predictive value of skinfold measurements for subsequent ischaemic heart disease at 14 years follow-up in the Caerphilly Study.
Yarnell JW, Patterson CC, Thomas HF, Sweetnam PM. Yarnell JW, et al. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1546-9. doi: 10.1038/sj.ijo.0801676. Int J Obes Relat Metab Disord. 2001. PMID: 11673779 - Adiposity assessment: explaining the association between obesity, hypertension and stroke.
Rhéaume C, Leblanc MÈ, Poirier P. Rhéaume C, et al. Expert Rev Cardiovasc Ther. 2011 Dec;9(12):1557-64. doi: 10.1586/erc.11.167. Expert Rev Cardiovasc Ther. 2011. PMID: 22103875 Review. - Body habitus and coronary heart disease in men. A review with reference to methods of body habitus assessment.
Williams SR, Jones E, Bell W, Davies B, Bourne MW. Williams SR, et al. Eur Heart J. 1997 Mar;18(3):376-93. doi: 10.1093/oxfordjournals.eurheartj.a015258. Eur Heart J. 1997. PMID: 9076375 Review.
Cited by
- Anthropometric Measures and Risk of Cardiovascular Disease: Is there an Opportunity for Non-Traditional Anthropometric Assessment? A Review.
Carrión-Martínez A, Buckley BJR, Orenes-Piñero E, Marín F, Lip GYH, Rivera-Caravaca JM. Carrión-Martínez A, et al. Rev Cardiovasc Med. 2022 Dec 20;23(12):414. doi: 10.31083/j.rcm2312414. eCollection 2022 Dec. Rev Cardiovasc Med. 2022. PMID: 39076676 Free PMC article. Review. - Crosstalk between FTO gene polymorphism (rs9939609) and obesity-related traits among Bangladeshi population.
Shill LC, Alam MR. Shill LC, et al. Health Sci Rep. 2023 Jul 8;6(7):e1414. doi: 10.1002/hsr2.1414. eCollection 2023 Jul. Health Sci Rep. 2023. PMID: 37431487 Free PMC article. - Growth and adiposity in newborns study (GAINS): The influence of prenatal DHA supplementation protocol.
Hull HR, Gajewski BJ, Sullivan DK, Carson SE. Hull HR, et al. Contemp Clin Trials. 2023 Sep;132:107279. doi: 10.1016/j.cct.2023.107279. Epub 2023 Jul 3. Contemp Clin Trials. 2023. PMID: 37406769 Free PMC article. - High-fat/high-sucrose diet worsens metabolic outcomes and widespread hypersensitivity following early-life stress exposure in female mice.
Frick JM, Eller OC, Foright RM, Levasseur BM, Yang X, Wang R, Winter MK, O'Neil MF, Morris EM, Thyfault JP, Christianson JA. Frick JM, et al. Am J Physiol Regul Integr Comp Physiol. 2023 Mar 1;324(3):R353-R367. doi: 10.1152/ajpregu.00216.2022. Epub 2023 Jan 24. Am J Physiol Regul Integr Comp Physiol. 2023. PMID: 36693166 Free PMC article. - Tea Plant (Camellia sinensis): A Current Update on Use in Diabetes, Obesity, and Cardiovascular Disease.
Brimson JM, Prasanth MI, Kumaree KK, Thitilertdecha P, Malar DS, Tencomnao T, Prasansuklab A. Brimson JM, et al. Nutrients. 2022 Dec 21;15(1):37. doi: 10.3390/nu15010037. Nutrients. 2022. PMID: 36615695 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical