Measurement of capillary filtration coefficient in a solid tumor - PubMed (original) (raw)
. 1991 Feb 15;51(4):1352-5.
Affiliations
- PMID: 1997172
Measurement of capillary filtration coefficient in a solid tumor
E M Sevick et al. Cancer Res. 1991.
Abstract
The net transvascular filtration rate, JF (ml/min/100 g), in an isolated, RBC-free perfused R3230AC mammary adenocarcinoma tumor was measured using a gravimetric method whereby changes in tissue weight over time were monitored. From the gravimetric measurements of JF following changes in venous pressure, the capillary filtration coefficient (ml/min/mm Hg/100 g) was found to be 2.2 (range, 0.8-2.8), i.e., 10 to 1000 times higher than those found in several normal tissues and within the range of those reported for glomerular capillaries. These measurements of capillary filtration coefficient are consistent with elevated tumor interstitial fluid pressure, interstitial fluid flow, and peritumor edema.
Similar articles
- Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.
Less JR, Skalak TC, Sevick EM, Jain RK. Less JR, et al. Cancer Res. 1991 Jan 1;51(1):265-73. Cancer Res. 1991. PMID: 1988088 - Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.
Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK. Netti PA, et al. Microvasc Res. 1996 Jul;52(1):27-46. doi: 10.1006/mvre.1996.0041. Microvasc Res. 1996. PMID: 8812751 - Distribution of body fluids: local mechanisms guarding interstitial fluid volume.
Aukland K. Aukland K. J Physiol (Paris). 1984;79(6):395-400. J Physiol (Paris). 1984. PMID: 6399307 Review.
Cited by
- Transport of drugs from blood vessels to tumour tissue.
Dewhirst MW, Secomb TW. Dewhirst MW, et al. Nat Rev Cancer. 2017 Dec;17(12):738-750. doi: 10.1038/nrc.2017.93. Epub 2017 Nov 10. Nat Rev Cancer. 2017. PMID: 29123246 Free PMC article. Review. - A tumor cord model for doxorubicin delivery and dose optimization in solid tumors.
Eikenberry S. Eikenberry S. Theor Biol Med Model. 2009 Aug 9;6:16. doi: 10.1186/1742-4682-6-16. Theor Biol Med Model. 2009. PMID: 19664243 Free PMC article. - 1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
Jain RK. Jain RK. Ann Biomed Eng. 1996 Jul-Aug;24(4):457-73. doi: 10.1007/BF02648108. Ann Biomed Eng. 1996. PMID: 8841721 Review. - Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
Jain RK. Jain RK. Cancer Metastasis Rev. 1990 Nov;9(3):253-66. doi: 10.1007/BF00046364. Cancer Metastasis Rev. 1990. PMID: 2292138 Review. - Sensitivity analysis of an image-based solid tumor computational model with heterogeneous vasculature and porosity.
Pishko GL, Astary GW, Mareci TH, Sarntinoranont M. Pishko GL, et al. Ann Biomed Eng. 2011 Sep;39(9):2360-73. doi: 10.1007/s10439-011-0349-7. Epub 2011 Jul 13. Ann Biomed Eng. 2011. PMID: 21751070 Free PMC article.