Levees of immunological tolerance - PubMed (original) (raw)

doi: 10.1038/ni.1833. Epub 2009 Dec 17.

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• PMID: 20016503
• DOI: 10.1038/ni.1833

Levees of immunological tolerance

Diane Mathis et al. Nat Immunol. 2010 Jan.

Abstract

Immunological tolerance guards against spurious immune responses to body constituents. Tolerance encompasses a network of mechanisms: central and peripheral, cell-autonomous and cell-interactive. Our understanding of these mechanisms has improved greatly over recent years, often reflecting new insights into the processes underlying particular autoimmune diseases. Yet it is possible that important tolerance mechanisms remain to be discovered, perhaps an explanation for the so-far disappointing clinical translation to the prevention and cure of autoimmune diseases.

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References

1. 1. Immunity. 2009 Aug 21;31(2):197-208 - PubMed
2. 1. Nat Med. 2000 Jan;6(1):56-61 - PubMed
3. 1. Nat Immunol. 2010 Jan;11(1):7-13 - PubMed
4. 1. J Immunol. 2008 Jun 15;180(12):7793-803 - PubMed
5. 1. Nat Immunol. 2010 Jan;11(1):41-4 - PubMed

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