Role of matrix metalloproteinase-9 in apoptosis of hippocampal neurons in rats during early brain injury after subarachnoid hemorrhage - PubMed (original) (raw)

Role of matrix metalloproteinase-9 in apoptosis of hippocampal neurons in rats during early brain injury after subarachnoid hemorrhage

Zongduo Guo et al. Neurol Sci. 2010 Apr.

Abstract

This study investigated the possible involvement of matrix metalloproteinase 9 (MMP-9) in early brain injury (EBI) of subarachnoid hemorrhage (SAH) in rats. MMP-9 activities in hippocampus were examined at 6, 12, 24, 48 and 72 h after SAH. Laminin was detected by immunohistochemistry. Apoptosis of neurons in hippocampus was observed by TUNEL. Brain water content was also examined. MMP-9 activity and the number of apoptotic neurons increased from 12 to 72 h with a peak at 24 h. Laminin was found to decrease at 12 h, reached minimum at 24 h and began to increase from 48 h, which had a negative correlation with apoptotic neurons. The changes of brain water content were found to be coincidence with that of neuronal apoptosis. Our findings suggest that MMP-9 is probably involved in the pathophysiological events of EBI after SAH, through degrading laminin which leads to neuronal anoikis of hippocampus.

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