Notch signaling in pancreatic endocrine cell and diabetes - PubMed (original) (raw)

Review

Notch signaling in pancreatic endocrine cell and diabetes

Wook Kim et al. Biochem Biophys Res Commun. 2010.

Abstract

Recent studies have improved our understanding of the physiological function of Notch signaling pathway and now there is compelling evidence demonstrating that Notch is a key regulator of embryonic development and tissue homeostasis. Although further extensive studies are necessary to illustrate the molecular mechanisms, new insights into the role of Notch signaling in pancreas development and diabetes have been achieved. Importantly, the ability to regulate Notch signaling intensity both positively and negatively may have therapeutic relevance for diabetes. Thus, this paper reviews the current knowledge of the roles of Notch signaling in the pancreatic endocrine cell system.

PubMed Disclaimer

Figures

Fig. 1

Fig. 1

Schematic model for pancreatic cell differentiation.

Fig. 2

Fig. 2

The bimodal pathway of Notch signaling during pancreas development. (a) Lateral inhibition. (b) Suppressive maintenance.

References

    1. Murtaugh LC, Melton DA. Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol. 2003;19:71–89. - PubMed
    1. collombat P, Hecksher-Sorensen J, Serup P, Mansouri A. Specifying pancreatic endocrine cell fates. Mech Dev. 2006;123:501–512. - PubMed
    1. Herrera PL. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development. 2000;127:2317–2322. - PubMed
    1. Pictet RL, Clark WR, Williams RH, Rutter WJ. An ultrastructural analysis of the developing embryonic pancreas. Dev Biol. 1972;29:436–467. - PubMed
    1. Gromada J, Franklin I, Wollheim CB. Alpha cells of the endocrine pancreas; 35 years of research but the enigma remains. Endocrine Rev. 2007;28:84–116. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources