Glucosamine induces autophagy via an mTOR-independent pathway - PubMed (original) (raw)
. 2010 Jan 22;391(4):1775-9.
doi: 10.1016/j.bbrc.2009.12.154. Epub 2010 Jan 5.
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- PMID: 20045674
- DOI: 10.1016/j.bbrc.2009.12.154
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Glucosamine induces autophagy via an mTOR-independent pathway
Tomoya Shintani et al. Biochem Biophys Res Commun. 2010.
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Abstract
Autophagy is a cellular process that nonspecifically degrades cytosolic components and is involved in many cellular responses. We found that amino sugars with a free amino group such as glucosamine, galactosamine and mannosamine induced autophagy via an mTOR-independent pathway. Glucosamine-induced autophagy at concentrations of at least 500 microM to over 40 mM. In the presence of 40 mM glucosamine, autophagy induction was initiated at 6h and reached a plateau at 36 h. Glucosamine-induced autophagy could remove accumulated ubiquitin-conjugated proteins as well as 79-glutamine repeats. Therefore, orally administered glucosamine could contribute to the prevention of neurodegenerative diseases and promotion of antiaging effects.
Copyright 2010 Elsevier Inc. All rights reserved.
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