Dissection of the bifunctional ARGRII protein involved in the regulation of arginine anabolic and catabolic pathways - PubMed (original) (raw)
Dissection of the bifunctional ARGRII protein involved in the regulation of arginine anabolic and catabolic pathways
H F Qui et al. Mol Cell Biol. 1991 Apr.
Abstract
ARGRII is a regulatory protein which regulates the arginine anabolic and catabolic pathways in combination with ARGRI and ARGRIII. We have investigated, by deletion analysis and fusion to LexA protein, the different domains of ARGRII protein. In contrast to other yeast regulatory proteins, 92% of ARGRII is necessary for its anabolic repression function and 80% is necessary for its catabolic activator function. We can define three domains in this protein: a putative DNA-binding domain containing a zinc finger motif, a region more involved in the repression activity located around the RNase-like sequence, and a large activation domain.
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References
- Cell. 1985 Dec;43(3 Pt 2):729-36 - PubMed
- Nature. 1970 Aug 15;227(5259):680-5 - PubMed
- Mol Cell Biol. 1985 Nov;5(11):3139-48 - PubMed
- Cell. 1986 Sep 12;46(6):885-94 - PubMed
- Cell. 1987 Mar 13;48(5):847-53 - PubMed
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