ERp57, a multifunctional endoplasmic reticulum resident oxidoreductase - PubMed (original) (raw)
Review
ERp57, a multifunctional endoplasmic reticulum resident oxidoreductase
Helen Coe et al. Int J Biochem Cell Biol. 2010 Jun.
Abstract
ERp57 is a 58-kDa thiol oxidoreductase and a member of the protein disulfide isomerase (PDI)-like family. ERp57 is highly similar to other PDI family members in terms of amino acid sequence and structural/functional domain organization; however, it possesses some distinctive structural features that dictate its unique functions in the cell. This protein plays an important role in endoplasmic reticulum quality control of newly synthesized glycoproteins, is critical in major histocompatability complex (MHC) class I assembly and regulates gene expression. Studies on ERp57-deficient mice indicate that the protein is critical during embryonic development. The protein has been implicated in human pathologies including cancer and Alzheimer's disease.
Copyright 2010 Elsevier Ltd. All rights reserved.
Similar articles
- Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells.
Molinari M, Helenius A. Molinari M, et al. Nature. 1999 Nov 4;402(6757):90-3. doi: 10.1038/47062. Nature. 1999. PMID: 10573423 - ERp57 and PDI: multifunctional protein disulfide isomerases with similar domain architectures but differing substrate-partner associations.
Maattanen P, Kozlov G, Gehring K, Thomas DY. Maattanen P, et al. Biochem Cell Biol. 2006 Dec;84(6):881-9. doi: 10.1139/o06-186. Biochem Cell Biol. 2006. PMID: 17215875 Review. - The cloning and inducible expression of the rainbow trout ERp57 gene.
Sever L, Bols NC, Dixon B. Sever L, et al. Fish Shellfish Immunol. 2013 Feb;34(2):410-9. doi: 10.1016/j.fsi.2012.11.001. Epub 2012 Nov 17. Fish Shellfish Immunol. 2013. PMID: 23165287 - Aggregate formation by ERp57-deficient MHC class I peptide-loading complexes.
Stepensky D, Bangia N, Cresswell P. Stepensky D, et al. Traffic. 2007 Nov;8(11):1530-42. doi: 10.1111/j.1600-0854.2007.00639.x. Epub 2007 Sep 6. Traffic. 2007. PMID: 17822402 - Interaction of ERp57 and tapasin in the generation of MHC class I-peptide complexes.
Garbi N, Hämmerling G, Tanaka S. Garbi N, et al. Curr Opin Immunol. 2007 Feb;19(1):99-105. doi: 10.1016/j.coi.2006.11.013. Epub 2006 Dec 5. Curr Opin Immunol. 2007. PMID: 17150345 Review.
Cited by
- ERp57 as a novel cellular factor controlling prion protein biosynthesis: Therapeutic potential of protein disulfide isomerases.
Sepulveda M, Rozas P, Hetz C, Medinas DB. Sepulveda M, et al. Prion. 2016;10(1):50-6. doi: 10.1080/19336896.2015.1129485. Prion. 2016. PMID: 26864548 Free PMC article. - Remifentanil Promotes PDIA3 Expression by Activating p38MAPK to Inhibit Intestinal Ischemia/Reperfusion-Induced Oxidative and Endoplasmic Reticulum Stress.
Shen J, Zhan Y, He Q, Deng Q, Li K, Wen S, Huang W. Shen J, et al. Front Cell Dev Biol. 2022 Jan 26;10:818513. doi: 10.3389/fcell.2022.818513. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35155431 Free PMC article. - Role of mitochondrial Ca2+ homeostasis in cardiac muscles.
Cao JL, Adaniya SM, Cypress MW, Suzuki Y, Kusakari Y, Jhun BS, O-Uchi J. Cao JL, et al. Arch Biochem Biophys. 2019 Mar 15;663:276-287. doi: 10.1016/j.abb.2019.01.027. Epub 2019 Jan 23. Arch Biochem Biophys. 2019. PMID: 30684463 Free PMC article. Review. - Proteomic analysis in pterygium; upregulated protein expression of ALDH3A1, PDIA3, and PRDX2.
Kim SW, Lee J, Lee B, Rhim T. Kim SW, et al. Mol Vis. 2014 Aug 27;20:1192-202. eCollection 2014. Mol Vis. 2014. PMID: 25221425 Free PMC article. - The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein.
Torres M, Medinas DB, Matamala JM, Woehlbier U, Cornejo VH, Solda T, Andreu C, Rozas P, Matus S, Muñoz N, Vergara C, Cartier L, Soto C, Molinari M, Hetz C. Torres M, et al. J Biol Chem. 2015 Sep 25;290(39):23631-45. doi: 10.1074/jbc.M114.635565. Epub 2015 Jul 13. J Biol Chem. 2015. PMID: 26170458 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous