Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function - PubMed (original) (raw)

Review

doi: 10.1038/nri2707.

Affiliations

• PMID: 20098461
• DOI: 10.1038/nri2707

Review

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

Maria T Abreu. Nat Rev Immunol. 2010 Feb.

Erratum in

• Nat Rev Immunol. 2010 Mar;10(3):215

Abstract

A single layer of epithelial cells lines the small and large intestines and functions as a barrier between commensal bacteria and the rest of the body. Ligation of Toll-like receptors (TLRs) on intestinal epithelial cells by bacterial products promotes epithelial cell proliferation, secretion of IgA into the gut lumen and expression of antimicrobial peptides. As described in this Review, this establishes a microorganism-induced programme of epithelial cell homeostasis and repair in the intestine. Dysregulation of this process can result in chronic inflammatory and over-exuberant repair responses, and it is associated with the development of colon cancer. Thus, dysregulated TLR signalling by intestinal epithelial cells may explain how colonic bacteria and inflammation promote colorectal cancer.

PubMed Disclaimer

References

1. 1. Gastroenterology. 2004 Feb;126(2):451-9 - PubMed
2. 1. Cell. 2004 Sep 17;118(6):671-4 - PubMed
3. 1. J Immunol. 2006 Apr 1;176(7):4275-83 - PubMed
4. 1. Mol Immunol. 2008 May;45(10):2929-36 - PubMed
5. 1. Nature. 2008 Oct 9;455(7214):804-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal