Requirement for nerve growth factor in the development of myelinated nociceptors in vivo - PubMed (original) (raw)

. 1991 Apr 11;350(6318):500-2.

doi: 10.1038/350500a0.

Affiliations

• PMID: 2014050
• DOI: 10.1038/350500a0

Requirement for nerve growth factor in the development of myelinated nociceptors in vivo

A M Ritter et al. Nature. 1991.

Abstract

In adult animals, sensory neurons innervating the skin are phenotypically diverse. We have now investigated whether nerve growth factor (NGF) has a physiological role in the development of this diversity. We gave antisera against NGF to rats from postnatal day 1 (PND 1) to adulthood (5 weeks). We found a virtually complete depletion of high threshold mechanoreceptors conducting in the A delta range (2-13 ms-1) in the sural nerve. This afferent type, normally present in large numbers, appeared to have been replaced by D-hair afferents, sensitive mechanoreceptors which normally are relatively rare. NGF deprivation had this effect only in early postnatal life; treatment from postnatal day 14 to adulthood had no effect. We conclude that the presence of NGF postnatally in skin is necessary for the proper phenotypic development of A delta cutaneous nociceptors.

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