The relationship between adipokines, metabolic parameters and insulin resistance in patients with metabolic syndrome and type 2 diabetes - PubMed (original) (raw)
. 2009 Nov-Dec;37(6):1803-12.
doi: 10.1177/147323000903700616.
Affiliations
- PMID: 20146878
- DOI: 10.1177/147323000903700616
Free article
The relationship between adipokines, metabolic parameters and insulin resistance in patients with metabolic syndrome and type 2 diabetes
J M Lee et al. J Int Med Res. 2009 Nov-Dec.
Free article
Abstract
This study was designed to investigate the relationship between adipokines in metabolic syndrome and insulin resistance. Sixty male and female subjects with or without metabolic syndrome and type 2 diabetes were included. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Compared with lean control subjects, patients with metabolic syndrome and type 2 diabetes had lower circulating levels of total adiponectin and high molecular weight (HMW) adiponectin, and higher levels of leptin and interleukin-6 (IL-6). Total and HMW adiponectin and the adiponectin/leptin (A/L) ratio were negatively correlated with HOMA-IR. After adjusting for age and sex, leptin, IL-6 and tumour necrosis factor-alpha (TNF-alpha) were positively correlated with HOMA-IR. After also adjusting for body mass index, HOMA-IR was found to be independently associated with leptin, A/L ratio and TNF-alpha levels. In conclusion, decreased total adiponectin and HMW adiponectin and increased leptin and IL-6 levels are characteristic of patients with metabolic syndrome and type 2 diabetes.
Similar articles
- Adiponectin, insulin resistance and clinical expression of the metabolic syndrome in patients with Type 2 diabetes.
Mojiminiyi OA, Abdella NA, Al Arouj M, Ben Nakhi A. Mojiminiyi OA, et al. Int J Obes (Lond). 2007 Feb;31(2):213-20. doi: 10.1038/sj.ijo.0803355. Epub 2006 Jun 6. Int J Obes (Lond). 2007. PMID: 16755284 - Insulin resistance, inflammatory biomarkers, and adipokines in patients with chronic kidney disease: effects of angiotensin II blockade.
de Vinuesa SG, Goicoechea M, Kanter J, Puerta M, Cachofeiro V, Lahera V, Gómez-Campderá F, Luño J. de Vinuesa SG, et al. J Am Soc Nephrol. 2006 Dec;17(12 Suppl 3):S206-12. doi: 10.1681/ASN.2006080916. J Am Soc Nephrol. 2006. PMID: 17130263 Clinical Trial. - [Correlation between the inflammatory factors and adipocytokines with gestational diabetes mellitus and their change in puerperium].
Liu T, Fang Z, Yang D, Liu Q. Liu T, et al. Zhonghua Fu Chan Ke Za Zhi. 2012 Jun;47(6):436-9. Zhonghua Fu Chan Ke Za Zhi. 2012. PMID: 22932110 Chinese. - [Adipocytokines and assay method in metabolic syndrome].
Abe A. Abe A. Rinsho Byori. 2010 Aug;58(8):823-9. Rinsho Byori. 2010. PMID: 20860176 Review. Japanese. - [The adiponectin to leptin ratio, a still unrecognized biomarker of insulin resistance and cardiometabolic risk].
Vatier C, Antuna-Puente B, Fellahi S, Vigouroux C, Capeau J, Bastard JP; groupe de travail RIHN Adipokines. Vatier C, et al. Ann Biol Clin (Paris). 2020 Jun 1;78(3):265-268. doi: 10.1684/abc.2020.1559. Ann Biol Clin (Paris). 2020. PMID: 32420886 Review. French.
Cited by
- Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis.
Chen Q, Lv J, Yang W, Xu B, Wang Z, Yu Z, Wu J, Yang Y, Han Y. Chen Q, et al. Theranostics. 2019 Aug 14;9(22):6424-6442. doi: 10.7150/thno.35528. eCollection 2019. Theranostics. 2019. PMID: 31588227 Free PMC article. Review. - The relationship of adiponectin/leptin ratio with homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy korean male adults.
Jung CH, Rhee EJ, Choi JH, Bae JC, Yoo SH, Kim WJ, Park CY, Mok JO, Kim CH, Lee WY, Oh KW, Park SW, Kim SW. Jung CH, et al. Korean Diabetes J. 2010 Aug;34(4):237-43. doi: 10.4093/kdj.2010.34.4.237. Epub 2010 Aug 31. Korean Diabetes J. 2010. PMID: 20835341 Free PMC article. - Maternal obesity, inflammation, and developmental programming.
Segovia SA, Vickers MH, Gray C, Reynolds CM. Segovia SA, et al. Biomed Res Int. 2014;2014:418975. doi: 10.1155/2014/418975. Epub 2014 May 20. Biomed Res Int. 2014. PMID: 24967364 Free PMC article. Review. - Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study.
Kim SH, Chung JH, Song SW, Jung WS, Lee YA, Kim HN. Kim SH, et al. Diabetol Metab Syndr. 2016 Feb 12;8:10. doi: 10.1186/s13098-016-0127-7. eCollection 2016. Diabetol Metab Syndr. 2016. PMID: 26877772 Free PMC article. - A combined continuous and interval aerobic training improves metabolic syndrome risk factors in men.
Sari-Sarraf V, Aliasgarzadeh A, Naderali MM, Esmaeili H, Naderali EK. Sari-Sarraf V, et al. Int J Gen Med. 2015 May 21;8:203-10. doi: 10.2147/IJGM.S81938. eCollection 2015. Int J Gen Med. 2015. PMID: 26056487 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical