Environmental factors and their timing in adult-onset multiple sclerosis - PubMed (original) (raw)

Review

Environmental factors and their timing in adult-onset multiple sclerosis

Adam E Handel et al. Nat Rev Neurol. 2010 Mar.

Abstract

Multiple sclerosis (MS) is a common, complex neurological disease. Epidemiological data implicate both genetic and environmental factors in the etiology of MS, with various factors interacting with one another. Environmental exposures might occur long before the disease becomes clinically evident, as suggested by the wide range in onset age. In this Review, we examine the key time periods during which the environment might contribute to MS susceptibility, as well as the potential environmental factors involved. Understanding the nature of environmental influences in MS is highly relevant to the development of public health measures that are aimed at preventing this debilitating disease.

PubMed Disclaimer

Similar articles

• Multiple sclerosis: risk factors, prodromes, and potential causal pathways.
  Ramagopalan SV, Dobson R, Meier UC, Giovannoni G. Ramagopalan SV, et al. Lancet Neurol. 2010 Jul;9(7):727-39. doi: 10.1016/S1474-4422(10)70094-6. Lancet Neurol. 2010. PMID: 20610348 Review.
• Genes, environment, and susceptibility to multiple sclerosis.
  Sotgiu S, Pugliatti M, Fois ML, Arru G, Sanna A, Sotgiu MA, Rosati G. Sotgiu S, et al. Neurobiol Dis. 2004 Nov;17(2):131-43. doi: 10.1016/j.nbd.2004.07.015. Neurobiol Dis. 2004. PMID: 15474351 Review.
• Environmental Influences on Risk and Disease Course in Pediatric Multiple Sclerosis.
  Dinov D, Brenton JN. Dinov D, et al. Semin Pediatr Neurol. 2023 Jul;46:101049. doi: 10.1016/j.spen.2023.101049. Epub 2023 Apr 25. Semin Pediatr Neurol. 2023. PMID: 37451747 Free PMC article.
• Environmental factors and multiple sclerosis.
  Ebers GC. Ebers GC. Lancet Neurol. 2008 Mar;7(3):268-77. doi: 10.1016/S1474-4422(08)70042-5. Lancet Neurol. 2008. PMID: 18275928 Review.
• Environmental factors in the development of multiple sclerosis.
  Michel L. Michel L. Rev Neurol (Paris). 2018 Jun;174(6):372-377. doi: 10.1016/j.neurol.2018.03.010. Epub 2018 May 4. Rev Neurol (Paris). 2018. PMID: 29735167 Review.

Cited by

• Association between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study.
  Jan RL, Ho CH, Sung CH, Wang JJ, Jan HY, Chen WY, Chang YS. Jan RL, et al. Front Neurol. 2024 Feb 27;15:1353326. doi: 10.3389/fneur.2024.1353326. eCollection 2024. Front Neurol. 2024. PMID: 38476197 Free PMC article.
• Neuroimaging Scoring Tools to Differentiate Inflammatory Central Nervous System Small-Vessel Vasculitis: A Need for Artificial Intelligence/Machine Learning?-A Scoping Review.
  Damer A, Chaudry E, Eftekhari D, Benseler SM, Safi F, Aviv RI, Tyrrell PN. Damer A, et al. Tomography. 2023 Oct 2;9(5):1811-1828. doi: 10.3390/tomography9050144. Tomography. 2023. PMID: 37888736 Free PMC article. Review.
• Decision trees to evaluate the risk of developing multiple sclerosis.
  Pasella M, Pisano F, Cannas B, Fanni A, Cocco E, Frau J, Lai F, Mocci S, Littera R, Giglio SR. Pasella M, et al. Front Neuroinform. 2023 Aug 15;17:1248632. doi: 10.3389/fninf.2023.1248632. eCollection 2023. Front Neuroinform. 2023. PMID: 37649987 Free PMC article.
• Genetic Basis of Inflammatory Demyelinating Diseases of the Central Nervous System: Multiple Sclerosis and Neuromyelitis Optica Spectrum.
  Ortiz GG, Torres-Mendoza BMG, Ramírez-Jirano J, Marquez-Pedroza J, Hernández-Cruz JJ, Mireles-Ramirez MA, Torres-Sánchez ED. Ortiz GG, et al. Genes (Basel). 2023 Jun 23;14(7):1319. doi: 10.3390/genes14071319. Genes (Basel). 2023. PMID: 37510224 Free PMC article. Review.
• Vitamins A and D Enhance the Expression of Ror-γ-Targeting miRNAs in a Mouse Model of Multiple Sclerosis.
  Mohammadi-Kordkhayli M, Sahraian MA, Ghorbani S, Mansouri F, Talebi F, Noorbakhsh F, Saboor-Yaraghi AA. Mohammadi-Kordkhayli M, et al. Mol Neurobiol. 2023 Oct;60(10):5853-5865. doi: 10.1007/s12035-023-03427-3. Epub 2023 Jun 23. Mol Neurobiol. 2023. PMID: 37353624

References

1. 1. Public Health Nutr. 2004 Apr;7(2):327-35 - PubMed
2. 1. J Neurol Neurosurg Psychiatry. 2008 Feb;79(2):152-7 - PubMed
3. 1. Mult Scler. 2008 Sep;14(8):1026-30 - PubMed
4. 1. J Neurol Neurosurg Psychiatry. 2005 Oct;76(10):1377-81 - PubMed
5. 1. Am J Ind Med. 2009 May;52(5):353-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Medical

  • MedlinePlus Health Information