High-density lipoprotein and the acute phase response - PubMed (original) (raw)
Review
High-density lipoprotein and the acute phase response
Anisa Jahangiri. Curr Opin Endocrinol Diabetes Obes. 2010 Apr.
Abstract
Purpose of review: Inflammation and the concomitant acute phase response induce marked changes in the lipoprotein profile, particularly the high-density lipoprotein (HDL) fraction. The present review describes the transfer proteins and lipases that remodel HDL and regulate its plasma levels, discusses the changes occurring in their activities during inflammation, and the influence of this altered remodeling on HDL function. The review will also discuss the contribution of the ATP-binding-membrane-cassette transporters to the protective actions of HDL.
Recent findings: Studies using different models showed that remodeling of acute phase HDL in vitro generates pre-beta migrating particles capable of cholesterol efflux. Induction of the acute phase response in humans resulted in a reduction of HDL phospholipids without a change in HDL-cholesterol. However, the capacity of HDL to promote cholesterol efflux ex vivo was impaired. Studies with ATP-binding-membrane-cassette transporter A1 and ATP-binding-membrane-cassette transporter G1 knockout mice demonstrated anti-inflammatory roles for these transporters by virtue of reducing cell-membrane-free cholesterol and lipid raft content, thus attenuating proinflammatory signaling pathways.
Summary: It is well known that HDL has anti-inflammatory properties that are diminished during inflammation. Acute phase HDL contains serum amyloid A that can be liberated during remodeling by cholesteryl ester transfer protein and secretory phospholipase A2, or other inflammatory factors. The ability of serum amyloid A and apolipoprotein A-I to promote cholesterol efflux may confer protective effects during the acute phase response.
Similar articles
- HDL remodeling during the acute phase response.
Jahangiri A, de Beer MC, Noffsinger V, Tannock LR, Ramaiah C, Webb NR, van der Westhuyzen DR, de Beer FC. Jahangiri A, et al. Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):261-7. doi: 10.1161/ATVBAHA.108.178681. Epub 2008 Nov 13. Arterioscler Thromb Vasc Biol. 2009. PMID: 19008529 Free PMC article. - Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1- but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein.
Favari E, Lee M, Calabresi L, Franceschini G, Zimetti F, Bernini F, Kovanen PT. Favari E, et al. J Biol Chem. 2004 Mar 12;279(11):9930-6. doi: 10.1074/jbc.M312476200. Epub 2003 Dec 29. J Biol Chem. 2004. PMID: 14701812 - Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1.
Umemoto T, Han CY, Mitra P, Averill MM, Tang C, Goodspeed L, Omer M, Subramanian S, Wang S, Den Hartigh LJ, Wei H, Kim EJ, Kim J, O'Brien KD, Chait A. Umemoto T, et al. Circ Res. 2013 May 10;112(10):1345-54. doi: 10.1161/CIRCRESAHA.111.300581. Epub 2013 Mar 15. Circ Res. 2013. PMID: 23501697 Free PMC article. - HDL cholesterol transport during inflammation.
van der Westhuyzen DR, de Beer FC, Webb NR. van der Westhuyzen DR, et al. Curr Opin Lipidol. 2007 Apr;18(2):147-51. doi: 10.1097/MOL.0b013e328051b4fe. Curr Opin Lipidol. 2007. PMID: 17353662 Review.
Cited by
- Dusty punch cards and an eternal enigma: high-density lipoproteins and atherosclerosis.
Kleber ME, Grammer TB, Kassner U, Silbernagel G, März W. Kleber ME, et al. Drugs. 2014 Apr;74(5):513-20. doi: 10.1007/s40265-014-0189-5. Drugs. 2014. PMID: 24691706 - Association between cardiometabolic risk factors and COVID-19 susceptibility, severity and mortality: a review.
Sharifi Y, Payab M, Mohammadi-Vajari E, Aghili SMM, Sharifi F, Mehrdad N, Kashani E, Shadman Z, Larijani B, Ebrahimpur M. Sharifi Y, et al. J Diabetes Metab Disord. 2021 Jun 26;20(2):1743-1765. doi: 10.1007/s40200-021-00822-2. eCollection 2021 Dec. J Diabetes Metab Disord. 2021. PMID: 34222055 Free PMC article. Review. - Transcriptomic and Proteomic Profiling Provides Insight into Mesangial Cell Function in IgA Nephropathy.
Liu P, Lassén E, Nair V, Berthier CC, Suguro M, Sihlbom C, Kretzler M, Betsholtz C, Haraldsson B, Ju W, Ebefors K, Nyström J. Liu P, et al. J Am Soc Nephrol. 2017 Oct;28(10):2961-2972. doi: 10.1681/ASN.2016101103. Epub 2017 Jun 23. J Am Soc Nephrol. 2017. PMID: 28646076 Free PMC article. - Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans.
Xie J, Zu Y, Alkhatib A, Pham TT, Gill F, Jang A, Radosta S, Chaaya G, Myers L, Zifodya JS, Bojanowski CM, Marrouche NF, Mauvais-Jarvis F, Denson JL. Xie J, et al. Diabetes Care. 2020 Aug 25;44(1):188-93. doi: 10.2337/dc20-1714. Online ahead of print. Diabetes Care. 2020. PMID: 32843337 Free PMC article. - Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH.
Kang GG, Trevaskis NL, Murphy AJ, Febbraio MA. Kang GG, et al. iScience. 2022 Dec 30;26(1):105905. doi: 10.1016/j.isci.2022.105905. eCollection 2023 Jan 20. iScience. 2022. PMID: 36691622 Free PMC article. Review.
References
- Barter P, Gotto AM, LaRosa JC, et al. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med. 2007;357:1301–1310. - PubMed
- Barter PJ, Nicholls S, Rye KA, et al. Antiinflammatory properties of HDL. Circ Res. 2004;95:764–772. - PubMed
- Lewis GF, Rader DJ. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res. 2005;96:1221–1232. - PubMed
- Gelissen IC, Harris M, Rye KA, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arterioscler Thromb Vasc Biol. 2006;26:534–540. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials