CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus - PubMed (original) (raw)

. 2010 Mar 19;327(5972):1518-22.

doi: 10.1126/science.1184178. Epub 2010 Feb 25.

Affiliations

• PMID: 20185686
• DOI: 10.1126/science.1184178

CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus

Jakob von Engelhardt et al. Science. 2010.

Abstract

CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus oocytes reduced GluA1- and A2-mediated steady-state currents, but did not affect kainate- or N-methyl-D-aspartate (NMDA) receptor-mediated currents. Mouse hippocampal CA1 pyramidal neurons expressed CKAMP44 at low abundance, and overexpression of CKAMP44 led to stronger and faster AMPA receptor desensitization, slower recovery from desensitization, and a reduction in the paired-pulse ratio of AMPA currents. By contrast, dentate gyrus granule cells exhibited strong CKAMP44 expression, and CKAMP44 knockout increased the paired-pulse ratio of AMPA currents in lateral and medial perforant path-granule cell synapses. CKAMP44 thus modulates short-term plasticity at specific excitatory synapses.

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Comment in

• Neuroscience. AMPA receptors--another twist?
  Farrant M, Cull-Candy SG. Farrant M, et al. Science. 2010 Mar 19;327(5972):1463-5. doi: 10.1126/science.1187920. Science. 2010. PMID: 20299582 No abstract available.
• Beyond TARPs: the growing list of auxiliary AMPAR subunits.
  Guzman SJ, Jonas P. Guzman SJ, et al. Neuron. 2010 Apr 15;66(1):8-10. doi: 10.1016/j.neuron.2010.04.003. Neuron. 2010. PMID: 20399724 No abstract available.

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